2012 Fiscal Year Final Research Report
Immune regulation by controlling vesicular functions in dendritic cells
| Project/Area Number |
22590434
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 自然免疫 / 樹状細胞 / 細胞内小胞 / 免疫制御 |
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| Research Abstract |
Plasmacytoid dendritic cells (pDCs) trigger autoimmune diseases by producing a large amount of IFN-alpha in response to nucleic acid. We found that the proteasome inhibitor bortezomib and the tyrosine kinase inhibitor dasatinib suppressed the IFN-alpha production by disturbing vesicular transport of nucleic acid-sensing Toll-like receptors and that of nucleic acid ligands, respectively. We thus obtained fundamental findings to develop novel immunosuppressants targeting vesicular functions in pDCs.
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[Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Tol l-like receptors and endoplasmic reticulum homeostasis2011
Author(s)
Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R,Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T
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Journal Title
Blood
Volume: 117
Pages: 500-509
DOI
Peer Reviewed
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[Presentation] A proteasome inhibitor bortezomib suppresses immunostimulatory activity of human plasmacytoid dendritic cells by targeting intracellular trafficking of Tol l-like receptor 9 and endoplasmic reticulum homeostasis.2010
Author(s)
Hirai M, Kadowaki N, Kitawaki T, Takaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T
Organizer
14thInternational Congress of Immunology
Place of Presentation
Kobe, Japan
Year and Date
20100822-27
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