2012 Fiscal Year Final Research Report
Studies of the immune regulation by IL-12-related immunosuppresive cytokines and their therapeutic application
| Project/Area Number |
22590435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARA Hiromitsu 佐賀大学, 医学部, 准教授 (20392079)
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| Project Period (FY) |
2010 – 2012
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| Keywords | IL-12 / 免疫 / 炎症 / 抑制 |
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| Research Abstract |
IL-27 is an IL-12-related cytokine with immunosuppressive function. In this study, we analyzed 1) immunosuppression on innate immunity by IL-27, 2) itsimmunosuppressive mechanisms, and 3) its therapeutic effects on immune and/or inflammatory diseases (in mouse models). We found that IL-27 regulated expression of Notch-related genes as well as lipid mediator-related genes, by which IL-27 may exert its novel immunoregulatory effects. We also found that involvement in and therapeutic effects of IL-27 on inflammation-induced metabolic diseases including atherosclerosis
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[Journal Article] Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells2013
Author(s)
Iwasaki, Y., F. Keishi, T. Okamura, A. Yanai, S. Sumitomo, H. Shoda, T. Tamura, H. Yoshida, P. Charnay, and K. Yamamoto.
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Journal Title
Peer Reviewed
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[Journal Article] Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis2012
Author(s)
Ozaki, N., S. Suzuki, M. Ishida, Y. Harada, K. Tanaka, Y. Sato, T. Kono, M. Kubo, D. Kitamura, J. Encinas, H. Hara, and H. Yoshida
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Journal Title
Int Immunol
Volume: 24
Pages: 539-550
Peer Reviewed
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[Journal Article] Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon2012
Author(s)
Jeon, S. G., H. Kayama, Y. Ueda, T. Takahashi, T. Asahara, H. Tsuji, N. M. Tsuji, H. Kiyono, J. S. Ma, T. Kusu, R. Okumura, H. Hara, H. Yoshida, M. Yamamoto, K. Nomoto, and K. Takeda
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Journal Title
PLoS Pathog
Volume: 8
Pages: e1002714
Peer Reviewed
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[Presentation] A novel IL-27 signaling pathway mediated by Egr-2 regulates IL-10 production in naive T cells2012
Author(s)
Iwasaki, Y., K. Fujio, T. Okamura, A. Yanai, S. Sumitomo, H. Shoda, T. Tamura, H. Yoshida, and K. Yamamoto
Organizer
第41回日本免疫学会学術集会
Place of Presentation
日本, 神戸
Year and Date
20121205-07
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[Presentation] Interleukin 27 Inhibits Hyperglycemia and Pancreatic Islet Inflammation Induced by Streptozotocin in Mice2010
Author(s)
Fujimoto, H., T. Hirase, Y. Miyazaki, H. Hara, N. Ide-Iwata, A. Nishimoto-Hazuku, C. J. M. Saris, H. Yoshida, and K. Node
Organizer
In The 14th International Congress of Immunology (ICI 2010)I
Place of Presentation
Japan, Kobe
Year and Date
20100822-27
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