2012 Fiscal Year Final Research Report
Role of GANP-mediated hypermutation
| Project/Area Number |
22590436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kumamoto University |
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Principal Investigator |
MAEDA Kazuhiko 熊本大学, 大学院・生命科学研究部, 助教 (20332869)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 免疫学 / ゲノム / 遺伝子 |
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| Research Abstract |
Activation-induced cytidine deaminase (AID) is essential to thegeneration for somatic hypermutation at immunoglobulin gene locus. However, it is unclearhow cytoplasmic AID shepherds from cytoplasm to nucleus toward the IgV locus. We studiedthe role of GANP-mediated somatic hypermutation in B cells. We showed that GANP forms acomplex with AID in the cytoplasm and relocated into the nucleus. We found that GANPregulates the recruitment of AID to the immunoglobulin variable regions by modulatingtranscription and nucleosome occupancy.
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Research Products
(9 results)
