To elucidate the roles of SOCS1 to regulate the differentiation of follicular helper T cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590438
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Keio University
• Principal Investigator: MORITA Rimpei 慶應義塾大学, 医学部, 講師 (00362541)
• Project Period (FY): 2010 – 2012
• Keywords: リンパ球 / 抗体産生 / SOCS1 / IL-21 / Th17

Research Abstract

The purposes of this study are to elucidate the effects of SOCS1 on the differentiation of effecter Th cells, especially follicular helper T cells. We successfully demonstrated that immunosuppressive T cells, Treg cells turned into exFoxp3 cells with losi

Research Products

• [Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis (2013)
  • Author(s): Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A.
  • Journal Title: Nat Immunol. Volume: 14 Pages: 230-7
  • DOI: doi:10.1038/ni.2520.
• [Journal Article] IL-23-independent induction of IL-17 from γδT cells and innate lymphoid cells promotes experimental intraocular neovascularization. (2013)
  • Author(s): Hasegawa E, Sonoda KH, Shichita T, Morita R, Sekiya T, Kimura A, Oshima Y, Takeda A, Yoshimura T, Yoshida S, Ishibashi T, Yoshimura A.
  • Journal Title: J Immunol. Volume: 190 Pages: 1778-87
  • DOI: doi:10.4049/jimmunol.1202495.
• [Journal Article] Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways. (2012)
  • Author(s): Sugiyama Y, Kakoi K, Kimura A, Takada I, Kashiwagi I, Wakabayashi Y, Morita R, Nomura M, Yoshimura A
  • Journal Title: Int. Immunol Volume: 24 Pages: 253-265
  • DOI: doi:10.1093/intimm/dxr126.
• [Journal Article] Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation.Biochem. Biophys. (2012)
  • Author(s): Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A.
  • Journal Title: Res. Commun. Volume: 418 Pages: 234-240
  • DOI: doi:10.1016/j.bbrc.2011.12.156.
• [Journal Article] Pyridone 6, a Pan-JAK Inhibitor, Ameliorates Allergic Skin Inflammation of NC/Nga Mice via Suppression of Th2 and Enhancement of Th17. (2011)
  • Author(s): Nakagawa R, Yoshida H, Asakawa M, Tamiya T, Inoue N, Morita R, Inoue H, Nakao A, Yoshimura A.
  • Journal Title: J Immunol. Volume: 187 Pages: 4611-4620
  • DOI: doi:10.4049/jimmunol.1100649.
• [Journal Article] SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production. (2011)
  • Author(s): Takahashi R, Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Asakawa M, Chinen T, Yoshimura A.
  • Journal Title: J Exp Med. Volume: 208 Pages: 2055-2067
  • DOI: doi:10.1084/jem.20110428.
• [Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin. (2011)
  • Author(s): Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, Morita R, Muto G, Shichita T, Takahashi R, Yoshimura A.
  • Journal Title: Immunity. Volume: 34 Pages: 741-754
  • DOI: doi:10.1016/j.immuni.2011.02.021.
• [Journal Article] The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4^ + T cells. (2011)
  • Author(s): Sekiya T, Kashiwagi I, Inoue N, MoritaR, Hori S, Waldmann H, Rudensky AY, Ichinose H, Metzger D, Chambon P, Yoshimura A.
  • Journal Title: Nature Communications.
  • DOI: doi:10.1038/ncomms1272
• [Journal Article] Human blood CXCR5+CD4+T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. (2011)
  • Author(s): Morita1 R, Schmitt N, Bentebibel SE, Ranganathan R, Bourdery L, Zurawski G,Foucat E, Dullaers M, Oh SK, SabzghabaeiN, Lavecchio EM, Punaro M, Pascual V,Banchereau J, Ueno H.
  • Journal Title: Immunity. Volume: 34 Pages: 108-121
  • DOI: doi:10.1016/j.immuni.2010.12.012.
• [Journal Article] 濾胞ヘルパーT細胞の分化誘導 (2011)
  • Author(s): 森田林平
  • Journal Title: 臨床免疫・アレルギー科 Volume: 56 Pages: 694-699
• [Presentation] Epigenetic modification induces CD8abexpressing double-positive T cells from human blood CD4+ T cells counterparts of T follicular cells (2012)
  • Author(s): 森田林平、吉村昭彦
  • Organizer: 第41回日本免疫学会学術集会・総会
  • Place of Presentation: 神戸
  • Year and Date: 20121205-07
• [Presentation] Human blood CXCR5+ CD4+ T cells are counterparts of T follicular cells (2011)
  • Author(s): 森田林平
  • Organizer: 第40回日本免疫学会学術集会・総会
  • Place of Presentation: 千葉
  • Year and Date: 20111127-29