2012 Fiscal Year Final Research Report
Analysis on the mechanism of immune regulation by CD200R3+ Naturally occurring regulatory dendritic cells
| Project/Area Number |
22590441
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SATO Katsuaki 独立行政法人理化学研究所, 樹状細胞機能研究チーム, チームリーダー (40301147)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 樹状細胞 / T細胞 / 免疫寛容 |
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| Research Abstract |
Deficiency of CD200R3 suppressed the T-cell regulatory function of naturally occurring regulatory dendritic cells. Furthermore, CD200R3+naturally occurring regulatory dendritic cell-deficient mice showed a more enhanced immune pathogenesis than wild-type mice. Therefore, our findings suggest that CD200R3 plays a crucial role in the T-cell regulatory function of naturally occurring regulatory dendritic cells.
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