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2012 Fiscal Year Final Research Report

Analysis of positive selection process during T eell development via large transcription factor

Research Project

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Project/Area Number 22590443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionInstitute for Developmental Research, Aichi Human Service Center (2011-2012)
The Institute of Physical and Chemical Research (2010)

Principal Investigator

TAKAGI Tsuyoshi  愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員 (70300879)

Project Period (FY) 2010 – 2012
Keywords転写因子 / positive selection / T細胞 / Zn-フィンガー
Research Abstract

Our bodies are protected from foreign bodies with sophisticated immune system. Establishment of acquired immune system should be highly regulated. Because destruction of this process means that ourselves might be exposed to attack from our immune cells. It is very important to understand how suitable T cells are selected to develop. In this study, I revealed how the transcription factor, that is essential for this process, regulates downstream genes to achieve it.

  • Research Products

    (4 results)

All 2013 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Deficiency of Schnurri-2, a MHC enhancer binding protein, induce mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizopherenia2013

    • Author(s)
      Keizo Takao, Katsunori Kobayashi, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Keiko Toyama, Hironori K Nakamura, Mahomi Kuroiwa, Jun Maeda, Kimie Atsuzawa, Kayoko Esaki, Shun Yamaguchi, Shigeki Furuya, Tsuyoshi Takagi, Noah M Walton, Nobuhiro Hayashi, Hidenori Suzuki, Makoto Higuchi, Nobuteru Usuda, Tetsuya, Suhara, Akinori Nishi, Mitsuyuki Matsumoto, Shunsuke Ishii & Tsuyoshi Miyakawa
    • Journal Title

      Neuropsychopharmacology

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Danpening of death pathway by schnurri-2 is essential for T cell development2011

    • Author(s)
      Tracy L. Staton, Vanja Lazarevic, Dallas C. Jones, Amanda J. Lanser, Tsuyoshi Takagi, Shunsuke Ishii & Laurie H. Glimcher
    • Journal Title

      Nature

      Volume: v472 Pages: 105-109

    • DOI

      DOI:10.1038/nature09848

    • Peer Reviewed
  • [Presentation] de novo型Sip1ヘテロ変異マウスを用いたMowat-Wilson syndromeのモデル動物としての有用性の検討2013

    • Author(s)
      高木豪, 東雄二郎
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-12-11
  • [Presentation] Positive selectionに必要なSchnurr-2のchip on chip法を用いた解析2010

    • Author(s)
      高木豪, 石井俊輔
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-14

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Published: 2014-08-29  

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