2012 Fiscal Year Final Research Report
The medical and social significance of the extension of RBC storage period from 3 weeks to 6 weeks
| Project/Area Number |
22590486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical sociology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 輸血副作用 / 血液製剤 / 細菌汚染 |
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| Research Abstract |
In Japan, red-cell concentrates manufactured in blood centers using the additive solution mannitol-adenine-phosphate（MAP）are required to be used within 3 weeks, although the shelf life had been 6 weeks until 1995. The main reason for the change was concern over contaminating bacteria, such as Yersinia Enterocolitica, which could grow even at low temperature (4℃). On the other hand, the demand for blood usage has gradually increased with an ageing society and a low birthrate. These changes have also decreased the number of blood donors. The situation has put further pressure on efforts to maintain an adequate blood supply. To resolve the issue, the risk of bacterial contamination of stored blood derived from donors with symptoms of infectious disease was estimated accurately, taking cost-effectiveness into account. On the basis of our data, the risk was extremely low even for various types of blood products. Therefore, the shelf life of packed red cells should be increased to 6 weeks as before.
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