2012 Fiscal Year Final Research Report
Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells
| Project/Area Number |
22590497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ABEI Masato 筑波大学, 医学医療系, 准教授 (20261802)
SUZUKI Hideo 筑波大学, 医学医療系, 准教授 (00400672)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 胃癌 / MDM2 / p53 |
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| Research Abstract |
Murine double minute 2 (MDM2) is a negative regulator of p53. An MDM2 inhibitor, nutlin-3, stabilized p53 and induced apoptosis in the gastric cell lines with wild-type p53. An in vivo antitumor effect of nutlin-3 alone and its additiveaugmentation by 5-fluorouracil were confirmed in MKN-45 xenograft tumor model. Nutlin-3 showed potent antitumor activity against human gastric cancer cells with wild-type p53 and shows promise as a single agent and in combination with conventional anticancer drugs.
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