2012 Fiscal Year Final Research Report
Genetic backgrounds of peripheral neuropathy induced by chemotherapy
| Project/Area Number |
22590500
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
MITSUMA Ayako 名古屋大学, 医学系研究科, 講師 (10467326)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Yuichi 名古屋大学, 医学部附属病院, 教授 (10360083)
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| Project Period (FY) |
2010 – 2012
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| Keywords | がん化学療法 / 医薬品副作用 / 遺伝子多型 |
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| Research Abstract |
Severe adverse effect often makes it impossible to continue anticancer chemotherapy. Oxaliplatin is one of the key drugs for adjuvant and palliative chemotherapy in colorectal cancer patients. Development of Oxaliplatin-induced peripheral neuropathy is cumulative and dose-limiting. Analysis of Japanese colorectal cancer patients revealed correlation between polymorphisms related to metabolism of Oxaliplatin and onset of neuropathies. This result is useful for identifying predictors of Oxaliplatin-induced neuropathy and may be useful for personalized chemotherapy. Ethical differences were also found compared to previous studies.
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[Journal Article] Genetic polymorphisms associated with oxaliplatin-induced peripheral neurotoxicity in Japanese patients with colorectal cancer2013
Author(s)
Tomoyo Oguri, Ayako Mitsuma, Megumi Inada-Inoue, Sachi Morita, Takashi Shibata, Tomoya Shimokata, Mihoko Sugishita, Goro Nakayama, Keisuke Uehara, Yoshinori Hasegawa, Yuichi Ando
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Journal Title
Int J Clin Pharmacol Ther
Volume: 51
Pages: 475-481
Peer Reviewed
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