2012 Fiscal Year Final Research Report
Visualization of angiogenesis in a mouse for evaluation of anti-angiogenesis drugs
| Project/Area Number |
22590501
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Ehime University |
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Principal Investigator |
INOUE Hirofumi 愛媛大学, 大学院・医学系研究科, 講師 (70321635)
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| Project Period (FY) |
2010 – 2012
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| Keywords | イメージング |
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| Research Abstract |
We generated mice which expressed Cre in the endothelial cellsto visualize tumor angiogenesis. We found that the luciferase activity increased in the tumor-forming region. Moreover, the activity was observed in the metastatic region of the lung. These findings indicate that development of tumor angiogenesis can be visualized by using these mice.
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