2012 Fiscal Year Final Research Report
Clinical Pharmacology research regarding cardiovascular biomarkers and experimental system for the assessment of drugs in humans
| Project/Area Number |
22590503
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
UEDA Shinichiro 琉球大学, 大学院・医学研究科, 教授 (80285105)
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| Co-Investigator(Kenkyū-buntansha) |
URATA Hidenori 福岡大学, 筑紫病院, 教授 (30289524)
MATSUOKA Hidehiro 久留米大学, 医学部, 教授 (80248393)
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| Project Period (FY) |
2010 – 2012
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| Keywords | バイオマーカー / 遊離脂肪酸 / 血管内皮機能 / 白血球活性化 / 酸化ストレス |
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| Research Abstract |
We need more specific, relevant and predictive biomarkers for not only daily practice but also development of new drugs for the prevention of cardiovascular events. Our research project firstly revealed that not only endothelial function but also smooth muscle responses to NO were impaired in not only diabetic but also IGT patients. These impaired vascular functions were significantly associated with insulin sensitivity. We also showed that elevation of FFA significantly impaired endothelial function, rheological function of myocardial microcirculation, insulin sensitivity and enhanced leukocyte function and angiotensin II forming activity. RAS inhibitors as well as dihydropyridine calcium antagonists significantly but not completely prevented these effects of FFA. We clarified mechanisms for FFA induced endothelial function and insulin resistance and established experimental system for the assessment antiatherosclerotic drugs in human.
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[Journal Article] Eicosapentaenoic acid (EPA) supplementation changes fatty acid composition and corrects endothelial dysfunction in hyperlipidemic patients2012
Author(s)
Yamakawa K, Shimabukuro M, Higa N, Asahi T, Ohba K, Arasaki O, Higa M, Oshiro Y, Yoshida H, Higa T, Saito T, Ueda S, Masuzaki M, Sata M
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Journal Title
Cardiol Res Pract
Pages: 754181
DOI
Peer Reviewed
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[Journal Article] OCEAN Study Group.Optimal Combination of Effective ANtihypertensives (OCEAN) study: a prospective, randomized, open-label2012
Author(s)
Kageyama S, Ueda S, Mochizuki K, Miyakawa M, Sugawara M, Nakayama M, Ohashi Y, Saito I, Saruta T
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Journal Title
blinded endpoint trial--rationale, design and results of a pilot study in Japan
Volume: 35
Pages: 221-7
Peer Reviewed
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[Journal Article] A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery.2012
Author(s)
Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Yamashina A
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Journal Title
Int Heart J
Volume: 53
Pages: 170-5
Peer Reviewed
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[Journal Article] Relationships among hyperuricemia, metabolic syndrome, and endothelial function2011
Author(s)
Tomiyama H, Higashi Y, Takase B, Node K, Sata M, Inoue T, Ishibashi Y, Ueda S, Shimada K, Yamashina A
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Journal Title
Am J Hypertens
Volume: 24
Pages: 770-4
Peer Reviewed
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[Journal Article] Combination Therapy of Hypertension to Prevent Cardiovascular Events Trial Group. Prevention of cardiovascular events with calcium channel blocker-based combination therapies in patients with hypertension: a randomized controlled trial2011
Author(s)
Matsuzaki M, Ogihara T, Umemoto S, Rakugi H, Matsuoka H, Shimada K, Abe K, Suzuki N, Eto T, Higaki J, Ito S, Kamiya A, Kikuchi K, Suzuki H, Tei C, Ohashi Y, Saruta T
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Journal Title
J Hypertens
Volume: 29
Pages: 1649-59
Peer Reviewed
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