2012 Fiscal Year Final Research Report
The expression of Toll-like receptor in myelodysplastic syndrome
| Project/Area Number |
22590515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Takayuki 群馬大学, 大学院・保健学研究科, 准教授 (80375542)
HANDA Hiroshi 群馬大学, 医学部, 講師 (90282409)
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| Co-Investigator(Renkei-kenkyūsha) |
(90282409)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 骨髄異形成症候群 / Toll-like receptor / apoptosis |
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| Research Abstract |
Myelodysplastic syndrome (MDS) is a clonal disease, characterized by ineffective hematopoiesis due to apoptosis of blood cells, progression to acute leukemia, and high frequency of autoimmune disease complications. Toll-like receptors (TLR) is reported to be involved in apoptosis, tumor immunity, and autoimmune disease. According to these, it is suspected that TLRs are associated with the pathogenesis of MDS. Twenty-one patients with MDS are included in this study. TLRs may be associated with the apoptosis of blood cells in high-risk MDS patients; however not be involved in the progression of MDS to leukemia.
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