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2012 Fiscal Year Final Research Report

Sudden coronary death, pokkuri disease, and lipoprotein-associated sphingosine 1-phosphate

Research Project

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Project/Area Number 22590517
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionGunma University

Principal Investigator

NAKAJIMA Katsuyuki  群馬大学, 大学院・保健学研究科, 客員教授 (10444051)

Co-Investigator(Kenkyū-buntansha) FUJITA Masaki  慶應義塾大学, 医学部, 教授 (00211524)
OKAJIMA Fumikazu  群馬大学, 生体調節研究所, 教授 (30142748)
Project Period (FY) 2010 – 2012
Keywordsスフィンゴシン 1-リン酸 / ポックリ病 / レムナント
Research Abstract

We have proposed that triglyceride-rich lipoprotein remnants are associated with the risk of sudden coronary death in younger cases without coronary atherosclerosis. However, it remains unclear how remnants are involved in coronary sudden death. In the present study, we tried to relate sphingosine1-phosphate (S1P), which is concentrated in lipoproteins, and apolipoprotein M, an S1P binding apolipoprotein, to sudden death. Our new assay method to detect S1P allowed to measure a low concentration of S1P in serum; however, there are any significant difference in S1P levels between normal and sudden death patients. We are now focusing on the difference in two dimensionalelectrophoresis pattern measured by anti-apoA-I and anti-apoM antidodies.

  • Research Products

    (25 results)

All 2012 2011 2010

All Journal Article (19 results) (of which Peer Reviewed: 18 results) Presentation (6 results)

  • [Journal Article] Comparative reactivity of remnant-like lipoprotein particles (RLP) and low-density lipoprotein (LDL) to LDL receptor and VLDL receptor: effect of a high-dose statin on VLDL receptor expression2012

    • Author(s)
      Imagawa M, Takahashi S, Zenimaru Y, Kimura T, Suzuki J, Miyamori I, Iwasaki T, Hattori H, Yamamoto TT, Nakano T, Nakajima K.
    • Journal Title

      Clin Chim Acta

      Volume: 413 Pages: 441-7

    • Peer Reviewed
  • [Journal Article] The characteristics of remnant lipoproteins in the fasting and postprandial plasma2012

    • Author(s)
      Nakajima K, Nakano T, Tokita Y, Nagamine T, Yatsuzuka S, Shimomura Y, Tanaka A, Sumino H, Nara M, Machida T, Murakami M.
    • Journal Title

      Clin Chim Acta

      Volume: 413 Pages: 1077-86

    • Peer Reviewed
  • [Journal Article] Remnant lipoproteins are a stronger risk factor for cardiovascular events than LDL-C from the studies of autopsies in sudden cardiac death cases.Recent Advances in Cardiovascular Risk Factors2012

    • Author(s)
      Nakajima K and Fujita MQ.
    • Journal Title

      Ed by Mehnaz Atiq. (Intech)

      Pages: 15-36

  • [Journal Article] Post-prandial remnant lipoprotein metabolism in autosomal recessive hypercholesterolaemia.2012

    • Author(s)
      Tada H, Kawashiri MA, Tanaka A, Nakano T, Nakajima K, Inoue T, Noguchi T, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M.
    • Journal Title

      Eur JClin Invest.

      Volume: 42 Pages: 1094-9

    • Peer Reviewed
  • [Journal Article] ELISA system for human endothelial lipase.2012

    • Author(s)
      Ishida T, Miyashita K, Shimizu M, Kinoshita N, Mori K, Sun L, Yasuda T, Imamura S, Nakajima K, Stanhope KL, Havel PJ, Hirata K.
    • Journal Title

      ClinChem

      Volume: 58 Pages: 1656-64

    • Peer Reviewed
  • [Journal Article] Advances in Clinical Chemistry (Review)2012

    • Author(s)
      Nakajima K, Nagamine T, Fijita MQ, Tanaka A. ApoB48
    • Journal Title

      submitted

    • Peer Reviewed
  • [Journal Article] Effects of maximal atorvastatin and rosuvastatin treatment on markers of glucose homeostasis and inflammation.2011

    • Author(s)
      Thongtang N, Ai M, Otokozawa S, Himbergen TV, Asztalos BF, Nakajima K, Stein E, Jones PH, Schaefer EJ.
    • Journal Title

      Am J Cardiol

      Volume: 107 Pages: 387-92

    • Peer Reviewed
  • [Journal Article] Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring Study2011

    • Author(s)
      Ai M, Otokozawa S, Asztalos BF, White CC, Cupples LA, Nakajima K, Lamon-Fava S, Wilson PW, Matsuzawa Y, Schaefer EJ
    • Journal Title

      Atherosclerosis

      Volume: 217 Pages: 543-8

    • Peer Reviewed
  • [Journal Article] Measurement of serum remnant-like lipoprotein particle-triglyceride (RLP-TG) and RLP-TG/ total TG ratio using highly sensitive triglyceride assayreagent2011

    • Author(s)
      Nakano T, Tokita Y, Nagamine T, Tanaka A, Okazaki M, Yatsuzuka S, Tarui N, Shimomura Y, Ando Y, Akamatsu S, Fujita MQ, Nakajima K
    • Journal Title

      Clin Chim Acta

      Volume: 12 Pages: 71-78

    • Peer Reviewed
  • [Journal Article] Particle size of apoB-48 carrying lipoproteins in remnant lipoproteins isolated from postprandial plasma2011

    • Author(s)
      Nakano T, Tanaka A, Okazaki M, Tokita Y, Nagamine T, Nakajima K.
    • Journal Title

      Ann Clin Biochem

      Volume: 48 Pages: 57-64

    • Peer Reviewed
  • [Journal Article] Postprandial lipoprotein metabolism: VLDL vs chylomicrons2011

    • Author(s)
      Nakajima K, Nakano T, Tokita Y, Nagamine T, Inazu A, Kobayashi J, Mabuchi H, Stanhope KL, Havel PJ, Okazaki M, Ai M, Tanaka A.
    • Journal Title

      Clin Chim Acta

      Volume: 412 Pages: 1306-1318

    • Peer Reviewed
  • [Journal Article] Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women.2011

    • Author(s)
      Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T, Chen G, Fong TH, Lee V, Menorca RI, Keim NL, Havel PJ.
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 96 Pages: 3783-91

    • Peer Reviewed
  • [Journal Article] Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions2011

    • Author(s)
      Stanhope KL, Griffen SC, Bremer AA, Vink RG, Schaefer EJ, Nakajima K, Schwarz JM, Beysen C, Berglund L, Keim NL, Havel PJ.
    • Journal Title

      Am J Clin Nutr

      Volume: 94 Pages: 112-9

    • Peer Reviewed
  • [Journal Article] Non-HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic population2011

    • Author(s)
      van Deventer HE, Miller WG, Myers GL, Sakurabayashi I, Bachmann LM, Caudill SP,Dziekonski A, Edwards S, Kimberly MM, Korzun WJ, Leary ET, Nakajima K, Nakamura M, Shamburek RD, Vetrovec GW, Warnick GR, Remaley AT
    • Journal Title

      Clin Chem

      Volume: 57 Pages: 490-501

    • Peer Reviewed
  • [Journal Article] Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma2010

    • Author(s)
      Nakajima K, Kobayashi J, Mabuchi H, Nakano T, Tokita Y, Nagamine T, Imamura S, Ai M, Otokozawa S, Schaefer EF
    • Journal Title

      Ann Clin Biochem

      Volume: 47 Pages: 423-31

    • Peer Reviewed
  • [Journal Article] Direct assessment of plasma low density lipoprotein and high density lipoprotein cholesterol levels and coronary heart disease: Results from the Framingham Offspring Study2010

    • Author(s)
      Otokozawa S, Ai M, Asztalos BF, White CC, Demissie-Banjaw S, Cupples LA, Nakajima K, Wilson PW, Schaefer EJ.
    • Journal Title

      Atherosclerosis

      Volume: 213 Pages: 251-5

    • Peer Reviewed
  • [Journal Article] Remaley ATSeven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures2010

    • Author(s)
      Miller WG, Myers GL, Sakurabayashi I, Bachmann LM, Caudill SP, Dziekonski A, Edwards S, Kimberly MM, Korzun WJ, Leary ET, Nakajima K, Nakamura M, Nilsson G, Shamburek RD, Vetrovec GW, Warnick GR
    • Journal Title

      Clin Chem.

      Volume: 56(6) Pages: 977-86

    • Peer Reviewed
  • [Journal Article] Small dense LDL cholesterol and coronary heart disease: results from the Framingham Offspring Study2010

    • Author(s)
      Ai M, Otokozawa S, Asztalos BF, Ito Y,Nakajima K, White CC, Cupples LA, Wilson PW, Schaefer EJ.
    • Journal Title

      Clin Chem

      Volume: 56 Pages: 967-76

    • Peer Reviewed
  • [Journal Article] Pokkuri Death Syndrome; Sudden Cardiac Death Cases without Coronary Atherosclerosis in South Asian Young Males.2010

    • Author(s)
      Nakajima K, Takeichi S, Nakajima Y, Fujita MQ.
    • Journal Title

      Forensic Sci Int

      Volume: 207 Pages: 6-13

    • Peer Reviewed
  • [Presentation] Panuwat Chutivongse, Nantana Sirisup, Sanae Takeichi, Masaki Q Fujita: The relationship between the severity of coronary artery atherosclerosis and heart weight in Asian sudden death cases2012

    • Author(s)
      Katsuyuki Nakajima Yasuhiro Nakajima
    • Organizer
      The XVI International Symposium on Atherosclerosis (ISA2012)
    • Place of Presentation
      Sydney Australia
    • Year and Date
      20120325-29
  • [Presentation] Ernst Schaefer Katsuyuki Nakajima: Plasma diagnostic markers of fatty liver in subjects with or without metabolic syndrome2012

    • Author(s)
      Shinichi Yatsuzuka, Masako Akuzawa, Masaki Takahashi, Younosuke Shimomura, Yoshitaka Ando, Isao Kobayashi, Takamitsu Nakano, Yoshiharu Tokita, Takeaki Nagamine, Hiromi Ono, Akira Tanaka
    • Organizer
      The XVI International Symposium on Atherosclerosis (ISA2012)
    • Place of Presentation
      Sydney Australia
    • Year and Date
      20120325-29
  • [Presentation] Effectof very-low-density lipoprotein (VLDL) Receptor on plasma triglyceride and the increased VLDL receptor expression by high dose statin, low fat and low glucose2012

    • Author(s)
      Michiko Imagawa, Sadao Takahashi1, Yasuo Zenimaru, Mai Ichikawa, Tomoko Kimura, Satsuki Sato, Jinya Suzuki, Isamu Miyamori, Takamitsu Nakano, Katsuyuki Nakajima
    • Organizer
      The XVI International Symposium on Atherosclerosis (ISA2012)
    • Place of Presentation
      Sydney Australia
    • Year and Date
      20120325-29
  • [Presentation] The characteristics of remnant lipoproteins in the fasting and postprandial plasma.2012

    • Author(s)
      Nakajima K, Nakano T, Y. Tokita, T. Nagamine, Yatsuzuka S, Shimomura Y, Tanaka A, Sumino H, Nara M, Machida T, Murakami M.
    • Organizer
      3rd International Symposium on Chylomicrons in Disease
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      20120323-24
  • [Presentation] The presence of postprandial remnant lipoproteins in the fasting plasma with TG levels below 150 mg/dL2011

    • Author(s)
      Nakajima K, Nakano T, Tokita Y, Nagamne T, Yatsuzuka S, Shimomura Y. Tanaka
    • Organizer
      American Association of Clinical Chemistry, Lipoproteins and Vascular Disease Division
    • Place of Presentation
      Atlanta, Georgia, USA
    • Year and Date
      20110724-27
  • [Presentation] Measurement of plasma remnant lipoproteins and its clinical significance2011

    • Author(s)
      Katsuyuki Nakajima
    • Organizer
      American Association of Clinical Chemistry, Lipoproteins and Vascular Disease Division
    • Place of Presentation
      Atlanta, Georgia, USA
    • Year and Date
      2011-07-25

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Published: 2014-08-29  

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