2012 Fiscal Year Final Research Report
Regulation of blood coagulation by RNase
| Project/Area Number |
22590519
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOYAMA Takatoshi 東京医科歯科大学, 大学院・保健衛生学研究科, 准教授 (20234916)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血液凝固 / RNA分解酵素 / 血管内皮細胞 |
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| Research Abstract |
RNA has been recognized as a novel procoagulatory and permeability-increasing factor and the function of it is counteracted by pancreatic-type ribonuclease (RNase 1). No detailed characterization of the expression and function of RNase in the vasculature were carried out so far. We aimed to investigate the expression and function of RNases in cells which come in contact with blood such as vascular endothelial cells, blood cells and malignant cells. The results indicate that endothelial RNase 1 may protect the vascular system against extracellular RNA released under pathological conditions. The RNA/RNase 1 in blood cells and malignant cells may play an additive role as a novel biological system contributing to the regulation and maintenance of vascular homeostasis.
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