2012 Fiscal Year Final Research Report
A new biomarker for atherosclerosis
| Project/Area Number |
22590528
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
ISHIDA Mari 広島大学, 大学院・医歯薬保健学研究院, 講師 (30359898)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Takafumi 広島大学, 大学院・医歯薬保健学研究院, 講師 (40346482)
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| Project Period (FY) |
2010 – 2012
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| Keywords | DNA 損傷 / DNA 修復 / DNA 損傷応答 / 動脈硬化 / DNA 二本鎖切断 |
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| Research Abstract |
The aim of this study is to find a biomarker for atherosclerosis or its comprehensive risk factors from the point of view of DNA damage/repair. The experiments using atherosclerotic mice lacking DNA damage response revealed that abnormality in DNA damage-repair accumulates DNA damage and accelerates atherosclerosis. According to the results, we established the method to quantify DNA damage, especially double strand breaks in human mononuclear cells. We showed that this method precisely detect one of the atherosclerotic risk factors, smoking. It isimportant for preventive medicine to further verify whether this method can estimateother risk factors comprehensively.
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