2012 Fiscal Year Final Research Report
Analysis of prognostic predictor for papillary thyroid carcinoma
| Project/Area Number |
22590536
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 甲状腺乳頭癌 / BRAF 遺伝子異常 / 臨床的悪性度 |
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| Research Abstract |
Analysis of BRAF mutation in papillary thyroid carcinoma using Fine-needle aspiration (FNA) sample is established in recent 3 years. We showed the relationship between BRAF mutation (T1796A) and clinical malignancy of Japanese PTC using FNA sample. In surgical PTC tissue,BRAF mutation (T1796A) is positive or negative, the direct sequence method revealed PTC with positive BRAF mutation had heterogeneous alleles. We are going to exclude wild type allele such as blood cells, mesenchymal cells and endothelial cells, further investigate the genetic heterogeneity .
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