Molecular epidemiology of metabolic syndrome and atherosclerosis initiating from genome wide association study

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590547
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MURAMATSU Masaaki 東京医科歯科大学, 難治疾患研究所, 教授 (50230008)
• Co-Investigator(Renkei-kenkyūsha): SAWABE Motoji 東京医科歯科大学, 教授 (30196331) ; MIYAKI Koici 国立国際医療センター研究所, 医療情報解析研究部, 室長 (20327498)
• Project Period (FY): 2010 – 2012
• Keywords: メタボリック症候群 / 動脈硬化症 / ゲノムワイド関連解析 / 遺伝因子と環境因子 / 交互作用

Research Abstract

We evaluated susceptibility genes/variations for metabolic syndrome and myocardial infarction in Japanese population, which were primarily found by GWAS in western population. We replicated some of their results in different phenotypes of metabolic syndrome, and also found novel gene-environment and gene-gene interactions in Japanese cohort. The effect of risk gene for myocardial infarction may be different between western and Japanese population.

Research Products

• [Journal Article] Thecombined impact of 12 common variants on hypertension in Japanese men, considering GWAS results (2012)
  • Author(s): Miyaki K, Htun NC, Song Y, Ikeda S, Muramatsu M, Shimbo T
  • Journal Title: J Hum Hypertens Volume: 26 Pages: 430-436
• [Journal Article] Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis a pathological study of1503 consecutive autopsy cases (2012)
  • Author(s): Ikeda S, Tanaka N, Arai T, Chida K, Muramatsu M, Sawabe M
  • Journal Title: Atherosclerosis Volume: 221 Pages: 458-60
• [Journal Article] J Atheroscler Thromb (2012)
  • Author(s): Ko MK, Ikeda S, Mieno-Naka M, Arai T, Zaidi SA, Sato N, Muramatsu M,Sawabe M
  • Journal Title: Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese Volume: 19 Pages: 552-8
• [Journal Article] Association of the catechol-O-methyl transferase gene Val158Met polymorphism with blood pressure and prevalence of hypertension: interaction with dietary energy intake (2011)
  • Author(s): Htun NC, Miyaki K, Song Y, Ikeda S, Shimbo T, Muramatsu M
  • Journal Title: Am J Hypertens Volume: 24 Pages: 1022-1026
• [Presentation] 他日本人高齢者における心筋梗塞関連遺伝子多型の冠動脈狭窄に対する影響 (2011)
  • Author(s): 池田仁子
  • Organizer: 日本人類遺伝学会第56回大会
  • Place of Presentation: 幕張
  • Year and Date: 2011-10-12
• [Presentation] Gene-environment interactions in metabolic syndrome andgenetic tests (2010)
  • Author(s): Muramatsu M
  • Organizer: 13th A-IMBN Symposium
  • Place of Presentation: Taipei
  • Year and Date: 20101111-14
• [Presentation] Nutrigenomics of MetabolicSyndrome (2010)
  • Author(s): Muramatsu M
  • Organizer: Aesthetics Asia2010
  • Place of Presentation: Singapore
  • Year and Date: 20100917-19
• [Book] 「遺伝子予防医療に対する期待」ウェルエイジングのための女性医療 (2011)
  • Author(s): 太田博明
  • Total Pages: 269-274
  • Publisher: 村松正明