2013 Fiscal Year Final Research Report
Carbamate pesticide-induced immunotoxicity and its mechanism
| Project/Area Number |
22590554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Nippon Medical School |
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Principal Investigator |
LI Qing 日本医科大学, 医学部, 准教授 (50250048)
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| Co-Investigator(Kenkyū-buntansha) |
KAWADA Tomoyuki 日本医科大学, 大学院医学研究科, 教授 (00224791)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 環境毒性学 / 免疫毒性学 / 農薬中毒 / アポトーシス / 抗癌タンパク / NK活性 / CTL活性 / LAK活性 |
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| Research Abstract |
Carbamate pesticides are widely used throughout the world in agriculture as fungicides and insecticides. Since carbamate pesticides contribute to chemical sensitivity and allergy related diseases; therefore, it is very important to investigate the immunotoxicity of carbamate pesticides and its mechanism in the perspecive of preventive medicine. In this study, we found that ziram, a carbamate fungicide, significantly inhibits natural killer (NK), lymphokine-activated killer (LAK) and cytotoxic T lymphocyte (CTL) activities. We have also found that ziram significantly induced apoptosis and necrosis in NK and T cells, and reduced the intracellular levels of anticancer proteins in NK cells, which contributed to the inhibitions of NK, LAK and CTL activities.
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