2012 Fiscal Year Final Research Report
A study on the relation of shift work on hormonal change and diseases of prostate
| Project/Area Number |
22590557
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIJO Muneko 金沢医科大学, 医学部, 准教授 (40198461)
SAKURAI Masaru 金沢医科大学, 医学部, 准教授 (90397216)
NAKAMURA Koshi 金沢医科大, 学医学部, 准教授 (80422898)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 産業衛生 |
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| Research Abstract |
We investigated the effects of night and shift work on cancer risk using serum prostatic specific antigen(PSA) and urinary 8-hydroxydeoxyguanosine (8-OHdG) as markers of cancer risk. However, we could not get the positive relationship between night and shift work and cancer risk. The study population consisted of 702 male employees aged 50-66 years in a factory in Japan. PSA level rose with increasing age, but not related with occupational factors including work schedule. The urinary8-OHdG level was the highest among the subjects engaged shift work without midnight shift, but statistically not significant.
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