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2012 Fiscal Year Final Research Report

Establishment of arteriosclerosis index related with leukocyte and platelet function measured by whole blood analysis method

Research Project

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Project/Area Number 22590560
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionYamagata University (2012)
Hyogo Medical University (2010-2011)

Principal Investigator

TAKEDA Yuji  山形大学, 医学部, 助教 (90302299)

Co-Investigator(Kenkyū-buntansha) MARUMO Mikio  兵庫医科大学, 医学部, 講師 (40333950)
WAKABAYASHI Ichiro  兵庫医科大学, 医学部, 教授 (70220829)
Project Period (FY) 2010 – 2012
Keywords予防医学 / 動脈硬化症 / 糖尿病合併症
Research Abstract

Increase in myocardial and cerebral infarction caused by arteriosclerosis is an importantissue in Japan, since the Japanese population is aging faster than any other in the world.Recently, pathology of arteriosclerosis is known as chronic inflammation of an arterial wall.However, there is no arteriosclerosis index using the function of leukocyte and platelet,which induce the progression of arteriosclerosis via inflammatory responses. In this study,the cell functions were measured in the model of diabetes, hyperlipidemia and turbulentblood flow, which are risk factors for arteriosclerosis, to examine whether the cell functions can be used for a new index of arteriosclerosis. The phagoytic activity of monocyte andgranulocyte were down-regulated in the diabetes and hyperlipidemia. Furthermore, a platelet-monocyte complex formation was selectively increased by turbulent blood flow.Therefore, these functional changes will be useful for an index to prevent the progression ofarteriosclerosis by an early intervention.

  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Alteration in lymphocyte population and humoral immune response in type 2 diabetic Goto-Kakizaki rats2012

    • Author(s)
      Takeda Y, Wakabayashi I.
    • Journal Title

      Life Sci

      Volume: 90 Pages: 545-52

    • DOI

      DOI:S0024-3205(12)00077-X [pii]

    • Peer Reviewed
  • [Journal Article] Attenuated phagocytic activity of monocytes in type 2 diabetic Goto-Kakizaki rats2011

    • Author(s)
      Takeda Y, Marumo M, Wakabayashi I.
    • Journal Title

      Immunobiology

      Volume: 216 Pages: 1094-102

    • DOI

      DOI:S0171-2985(11)00095-7 [pii]

    • Peer Reviewed
  • [Presentation] 2型糖尿病自然発症ラットにおける単球貪食能と液性免疫反応の変化2012

    • Author(s)
      武田裕司,浅尾裕信,丸茂幹雄,若林一郎
    • Organizer
      第66回日本細菌学会東北支部
    • Place of Presentation
      日仙台東北大学片平さくらホール
    • Year and Date
      2012-08-23
  • [Presentation] 2型糖尿病自然発症ラットにおける末梢血中の好中球・単球機能のフローサイトメトリー解析2011

    • Author(s)
      武田裕司,丸茂幹雄,若林一郎
    • Organizer
      第21回日本サイトメトリー学会学術集会
    • Place of Presentation
      日京都京都市国際交流会館
    • Year and Date
      2011-06-25
  • [Presentation] 2型糖尿病自然発症ラットにおける単球機能の変化2010

    • Author(s)
      武田裕司,丸茂幹雄,若林一郎
    • Organizer
      第80回日本衛生学学会
    • Place of Presentation
      日仙台仙台国際センター
    • Year and Date
      2010-05-09

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Published: 2014-08-29  

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