Persistent on-going myocardial necrosis in general population

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590564
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Kurume University
• Principal Investigator: NIIYAMA Hiroshi 久留米大学, 医学部, 助教 (30309778)
• Co-Investigator(Kenkyū-buntansha): ANEGAWA Takahiro 久留米大学, 医学部, 助教 (00511833) ; YASUOKA Suguru 久留米大学, 医学部, 助教 (10461435) ; ADACHI Hisashi 久留米大学, 医学部, 教授 (40212518) ; KAJIMOTO Hidemi 久留米大学, 循環器病研究所, 助教 (50349700) ; KAI Hisashi 久留米大学, 医学部, 准教授 (60281531) ; TAKEMIYA Kiyoko 久留米大学, 医学部, 助教 (20535075)
• Project Period (FY): 2010 – 2012
• Keywords: 予防医学 / 心筋障害 / 心不全 / 心血管障害 / マーカー

Research Abstract

Circulating high-sensitivity cardiac troponin T (hsTnT) levels are highlighted as a biomarker reflecting persistent, on-going myocardial damages. We sought to examine the correlation between hsTnT levels and conventional cardiovascular risk factors and surrogate markers for cardiovascular events in healthy general subjects who were registered in the Tanushimaru study. hsTnT was detected (the cut-off level: >0.003 ng/mL) in approximately 40% of 2,100 healthy subjects. Univariate analysis reveled that age, estimated glomerular filtration rate (eGFR)(inversely), hypertension, intima-media thickness, and serum uric acid were significantly associated with hsTnT levels. Multiple regression analysis showed that only age was a significant determinant factor for hsTnT levels (p<0.001). Next, we examined the correlation between the incidence of atrial fibrillation (AF) and hsTnT levels in healthy general subjects in Uku study. Multiple regression analysis revealed that eGFR (p<0.001) and sTnT levels (p=0.012) were significant determinant factor for AF. Adjusted hsTnT levels were significantly greater in the subjects with AF than in the non-AF subjects (p=0.015). Moreover, the incidence of AF was positively associated with the quartile stratified by increasing hsTnT levels (p=0.003).

Research Products

• [Journal Article] Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion. (2010)
  • Author(s): Huang NF, Niiyama H
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 30 Pages: 984-991
  • Peer Reviewed
• [Presentation] Candesartan-based Treatment for Variability Lowering of Individual Blood Pressure and Heart Rate at Home Study: CAVALIERat HOME. (2013)
  • Author(s): Kai H
  • Organizer: 日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130315-0317
• [Presentation] 非弁膜性心房細動を有する脳梗塞患者からみたCHADS2スコア、CHA2DS2-VAScスコア. (2012)
  • Author(s): 姉川敬裕、甲斐久史、梶本英美
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 20120914-0916
• [Presentation] Increased circulating asymmetricdimethylarginine in chronic kidney disease mice induces endothelial dysfunction by inhibiting Ca/Calmodulin-dependent protein kinase II-eNOS signaling. (2010)
  • Author(s): Kajimoto H, Kai H
  • Organizer: American Heart Association Scietific Meeting2010
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 20101114-1117
• [Presentation] Eplerenone prevented the large blood pressurevariability-induced aggravation of cardiac remodeling by inhibiting of perivascular inflammation in spontaneously hypertensive rats. (2010)
  • Author(s): Yasuoka S, Kai
  • Organizer: European Society of CardiologyCongress 2010
  • Place of Presentation: Stockholm , Sweden
  • Year and Date: 20100828-0915
• [Presentation] Low diastolic blood pressure is not an independent risk for cardiovascular death inrevascularized coronary artery disease patients. (2010)
  • Author(s): Kai H, Niiyama H
  • Place of Presentation: Paris, France
  • Year and Date: 20100827-0915