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2012 Fiscal Year Final Research Report

Mechanism analyses of development of cardiovascular lesions in long-time workers by multi-biomarkers.

Research Project

  • PDF
Project/Area Number 22590582
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNagoya University

Principal Investigator

HIRAI Makoto  名古屋大学, 医学系研究科(保健), 教授 (90242875)

Co-Investigator(Kenkyū-buntansha) TAMAKOSHI Koji  名古屋大学, 医学系研究科(保健), 教授 (30262900)
Co-Investigator(Renkei-kenkyūsha) SAKAKIBARA Hisataka  名古屋大学, 医学系研究科(保健), 教授 (80153873)
Project Period (FY) 2010 – 2012
Keywordsバイオマーカー / 心血管 / 長時間労働 / 酸化LDL / MDA-LDL
Research Abstract

Working long hours increases cardiovascular diseases even in young workers. However, the mechanisms for this have not yet been elucidated. We analyzed biomarkers to clarify the pathobiochemical mechanisms involved in the development of cardiovascular diseases induced by working long hours in Japanese office workers. In office workers who worked over 240 hours a month (> 80 hours of overtime work a month), we measured the following: interleukin-6; matrix metalloproteinase-9; tumor necrosis factor-α; adiponectin; small dense low-density lipoprotein (LDL); malondialdehyde-modified LDL (MDA-LDL); total cholesterol; LDL cholesterol; high-density lipoprotein cholesterol; homocysteine; pentraxin 3; and high-sensitivity C-reactive protein. Of the workers, 77.4% had abnormally high MDA-LDL. The same markers were measured again when their working hours were shorter than 240 hours a month. With shorter working hours compared to working hours > 240 hours a month, the ratio of MDA-LDL to LDL significantly decreased. There were no significant changes in other biomarkers between the longer and shorter working hours. These findings suggest that working long hours might accelerate the formation of atherosclerotic lesions. Monitoring the ratio of MDA-LDL to total LDL might provide useful information for the healthcare of workers with long working hours. Lowering oxidized LDL might be of importance and beneficial in preventing cardiovascular events in office workers with long working hours.

  • Research Products

    (13 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] Relation of plasma catecholamine levels with pulse wave velocity in hypertensive patients compared with normotensive subjects2012

    • Author(s)
      Yamada K, Iino S, Isobe S, Kondo T, Izawa H, Inden Y, Yoshikane M, Ikeda N, Hirai M, Sawada K, Murohara T
    • Journal Title

      Heart Vessels

      Volume: 27(5) Pages: 493-8

    • Peer Reviewed
  • [Journal Article] Diagnostic usefulness of the oedema-infarct ratio to differentiate acute from chronic myocardial damage using magnetic resonance imaging.2012

    • Author(s)
      Yamada K, Isobe S, Suzuki S, Kinoshita K, Yokouchi K, Iwata H, Ohshima S, Hirai M, Sawada K, Murohara T
    • Journal Title

      Eur Radiol

      Volume: 22 Pages: 789-795

    • Peer Reviewed
  • [Journal Article] Can acute myocardial infarction sneak out from takotsubo?2012

    • Author(s)
      Hirai M
    • Journal Title

      Circ J

      Volume: 76 Pages: 305-306

    • Peer Reviewed
  • [Journal Article] Statin treatment for patients with paroxysmal atrial fibrillation2011

    • Author(s)
      Watanabe E, Yamashita T, Suzuki S, Saikawa T, Hirai M, Yamazaki T, Ohtsu H, Ogawa S
    • Journal Title

      Int Heart J

      Volume: 52 Pages: 103-106

    • Peer Reviewed
  • [Journal Article] Morphological characteristics of the holter p-waves associated with pulmonary vein pacing2010

    • Author(s)
      Harata S, Inden Y, Shimano M, Uchikawa T, Mutoh M, Hirai M, Murohara T
    • Journal Title

      Europace

      Volume: 12 Pages: 124-129

    • Peer Reviewed
  • [Presentation] 循環器疾患患者の在宅運動療法支援に向けた自律神経活動指標の応用に基づく研究-活動量・活動強度と自律神経活動指標-2013

    • Author(s)
      中山奈津紀、平井眞理
    • Organizer
      第77回日本循環器病学会
    • Place of Presentation
      横浜
    • Year and Date
      20130315-17
  • [Presentation] The Predictor of Left Atrial Appendage Dysfunction in Patients with CHADS2 Score of 02013

    • Author(s)
      YOSHIDA Naoki、INDEN Yasuya, YAMAMOTO Toshihiko, OHGUCHI Shiou, MIYATA Shinjiro, TAGUCHI Noriko, FUJITA Masaya, YOKOI Kenichiro, KUMAGAI Soichiro, SHIMANO Masayuki, HIRAI Makoto, MUROHARA Toyoaki
    • Organizer
      The 77th Annual Scientific Meeting of Japan Circulation Society
    • Place of Presentation
      Yokohama
    • Year and Date
      20130315-17
  • [Presentation] A New Electrocardiographic Criterion for Differentiating Left from Right Ventricular Outflow Tract-Tachycardia Origin: The V4 R-wave Amplitude Ratio2013

    • Author(s)
      YOSHIDA Naoki、INDEN Yasuya, YAMAMOTO Toshihiko, OHGUCHI Shiou, MIYATA Shinjiro, TAGUCHI Noriko, Fujita Masaya, YOKOI Kenichiro, KUMAGAI Soichiro, SHIMANO Masayuki, HIRAI Makoto, MUROHARA Toyoaki
    • Organizer
      The 77th Annual Scientific Meeting of Japan Circulation Society
    • Place of Presentation
      Yokohama
    • Year and Date
      20130315-17
  • [Presentation] The Diagnostic Value of the QWave Amplitude Ratio in Lead aVR for Differentiating the Outflow Tract Ventricular Arrhythmia Origin2013

    • Author(s)
      YOSHIDA Naoki、INDEN Yasuya, YAMAMOTO Toshihiko, OHGUCHI Shiou, MIYATA Shinjiro, TAGUCHI Noriko, FUJITA Masaya, YOKOI Kenichiro, KUMAGAI Soichiro, SHIMANO Masayuki, HIRAI Makoto, MUROHARA Toyoaki
    • Organizer
      The 77th Annual Scientific Meeting of Japan Circulation Society
    • Place of Presentation
      Yokohama
    • Year and Date
      20130315-17
  • [Presentation] Life activities improve heart rate variability in patients with d hypertension and/or heart failure2012

    • Author(s)
      Nakayama N, Negi K, Watanabe K, Hirai M
    • Organizer
      2012 Nagoya-Yonsei University Research Exchange Meeting on Health Sciences
    • Place of Presentation
      Nagoya
    • Year and Date
      20121122-24
  • [Presentation] 長時間労働者における心血管系バイオマーカーの検討2012

    • Author(s)
      平井真理、玉腰浩司、榊原久孝
    • Organizer
      第71回日本公衆衛生学会総会
    • Place of Presentation
      山口
    • Year and Date
      20121024-26
  • [Presentation] 循環器疾患患者の在宅運動療法支援に向けた自律神経活動指標の応用に基づく研究 維持期における日常生活活動量と自律神経-2012

    • Author(s)
      中山奈津紀、平井眞理
    • Organizer
      第60回 日本心臓病学会
    • Place of Presentation
      金沢
    • Year and Date
      20120914-16
  • [Presentation] 循環器疾患患者の在宅運動療法支援に向けた自律神経活動指標の応用に基づく研究2012

    • Author(s)
      中山奈津紀、平井眞理
    • Organizer
      第76回 日本循環器病学会
    • Place of Presentation
      福岡
    • Year and Date
      20120316-18

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Published: 2014-08-29  

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