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2012 Fiscal Year Final Research Report

Correlation of Epidemic Norovirus infection with its antigenicity

Research Project

  • PDF
Project/Area Number 22590597
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionOsaka Prefecture University

Principal Investigator

SETO Yoshiyuki  大阪府立大学, 生命環境科学研究科, 准教授 (70270759)

Co-Investigator(Renkei-kenkyūsha) IRITANI Nobuhiro  大阪市立環境科学研究所, 研究員 (70300994)
Project Period (FY) 2010 – 2012
Keywords地域保健
Research Abstract

To clarify epidemics of Norovirus infection, we examined genetic and antigenetic diversity of Norovirus GII.2 and GII.6 strains periodically detected in Osaka city Japan using the VLPs. Although each variant GII.2 strains possessed different antigenicity, did not change the hist-blood group antigen(HBGA) binding ability. These GII.2 variant strains were considered as neutralize escape mutant. Norovirus GII.6 strains werefurther classified into 3 genetic clusters, and the HBGA binding ability and the antigenicity differed each other. The periodically epidemics of Norovirus GII.6 strains were occurred by at least 3 different variants.

  • Research Products

    (11 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Improved detection methods by genetic and immunological techniques for botulinum C/D and D/C mosaic neurotoxins2013

    • Author(s)
      Nakamura K, Kohda T, Seto Y, Mukamoto M, Kozaki S.
    • Journal Title

      Veterinary Microbiology

      Volume: 162 Pages: 881-890

    • Peer Reviewed
  • [Journal Article] Increase of GII.2 Norovirus infection during the 2009-2010 season in Osaka city, Japan2012

    • Author(s)
      Iritani N, Kaida A, Abe N. Sekiguchi J, Kubo H, Takakura K, Goto K, Ogura H, Seto Y
    • Journal Title

      Journal of medical Virology

      Volume: 184 Pages: 517-525

    • Peer Reviewed
  • [Journal Article] The stability of toxigenicity in proteolytic Clostridium botulinum type B upon serial passage.2012

    • Author(s)
      Umeda K, Seto Y, Kohda T, Mukamoto M, Kozaki S.
    • Journal Title

      Microbiology and Immunology

      Volume: 56 Pages: 338-341

    • Peer Reviewed
  • [Journal Article] Molecular epidemiology of Noroviruses detected in seasonal outbreaks of acute nonbavterial gastroenteritis in Osaka city, Japan, from 1996 - 1997 to 2008 - 2009.2010

    • Author(s)
      Iritani N, Kaida A, Kubo H, Abe N, Goto K, Ogura H, Seto Y
    • Journal Title

      Journal of Medical Virology

      Volume: 82 Pages: 2097-2105

    • Peer Reviewed
  • [Journal Article] A novel multiplex PCR method for Clostridium botulinum neurotoxin type A gene cluster typing2010

    • Author(s)
      Umeda K, Seto Y, Kohda T, Mukamoto M, Kozaki S
    • Journal Title

      Microbiology and Immunology

      Volume: 54 Pages: 308-312

    • Peer Reviewed
  • [Presentation] 大阪市内で検出された Norovirus GII.6の抗原性および組織血液型抗原結合能について2012

    • Organizer
      第60回日本ウイルス学会総会
    • Place of Presentation
      大阪
    • Year and Date
      20120000
  • [Presentation] ノロウイルスに効果のある食品添加物・食品素材の探索2011

    • Organizer
      第32回日本食品微生物学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      20110000
  • [Presentation] 抗菌複合における抗ウイルス効果2011

    • Organizer
      第32回日本食品微生物学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      20110000
  • [Presentation] 2009/10 シーズンに大阪市で認められた GII.2 型ノロウイルスの流行2010

    • Organizer
      第58回日本ウイルス学会総会
    • Place of Presentation
      徳島
    • Year and Date
      20100000
  • [Patent(Industrial Property Rights)] ウイルス不活化組成物2011

    • Inventor(s)
      國武広一郎、勢戸祥介
    • Industrial Property Rights Holder
      國武広一郎、勢戸祥介
    • Industrial Property Number
      特願 2011-149576
    • Filing Date
      2011-07-05
  • [Patent(Industrial Property Rights)] 殺ウイルス組成物2011

    • Inventor(s)
      田坂寛之、勢戸祥介
    • Industrial Property Rights Holder
      田坂寛之、勢戸祥介
    • Industrial Property Number
      特願 2011-186419
    • Filing Date
      2011-08-29

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Published: 2014-08-29  

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