Study on the evaluation of new biomarker's predictability of the onset of atherothrombosis

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590601
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Iwate Medical University
• Principal Investigator: SAKATA Kiyomi 岩手医科大学, 医学部衛生学公衆衛生学講座, 教授 (50225794)
• Co-Investigator(Kenkyū-buntansha): HITOMI Jiro (00218728)
• Project Period (FY): 2010 – 2012
• Keywords: バイオマーカー / アテローム血栓症

Research Abstract

Utilizing 468 preserved serums used for cohort studies whose initial follow-up was more than 6 years ago, serum levels of S100A12 protein and breakdown product of complement component C3a were measured, and comparison with their baseline results was made.Spearman’s coefficient of correlation of the serum concentration between S100A12 and C3a was 0.504 with p-value ≦ 0.0001. The correlation coefficients of S100A12 concentration with the level of triglyceride and that with leukocyte counts were significant. The correlation coefficients of the concentration of the breakdown product of C3a with HDL cholesterol level, leukocyte counts, blood sugar level, HbAlc, systolic blood pressure, diastolic blood pressure, and Body Mass Index were also significant. Neither existing condition nor incident stroke had significant association with S100A12 or C3a.

Research Products

• [Journal Article] Influence of the Great East Japan Earthquake and Tsunami 2011 on Occuerrence of Cerebrovascular Diseases in Iwate,Japan. (2013)
  • Author(s): Shinichi Omama, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Nakamura M, Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K.
  • Journal Title: Stroke Volume: 44(6) Pages: 1518-1524
  • Peer Reviewed
• [Journal Article] Prediction of Carotid Plaque characteristics using non-gated MR imaging: correlation with endoarterectomy specimens. (2013)
  • Author(s): Narumi S, Sakaki M, Ohba H, Ogasawara K, Kobayashi M, Hitomi J, Mori K, Ohura K, Yamaguchi M, Kudo K, Terayama Y
  • Journal Title: Am J Neuroradiol Volume: 34(1) Pages: 191-197
  • Peer Reviewed
• [Journal Article] Influence of mild-to-moderate alcohol consumption on cardiovascular diseases in men from the general population (2012)
  • Author(s): Makita S, Onoda T, Ohsawa M, Tanaka F, Segawa T, Takahashi T, Satoh K, Itai K, Tanno K, Sakata K, Omama S, Yoshida YIshibashi Y, Koyama T, Kuribayashi T, Ogasawara K, Ogawa A, Okayama A, Nakamura M.
  • Journal Title: Atherosclerosis Volume: 224 Pages: 222-227
  • Peer Reviewed
• [Journal Article] Poor self-rated health is significantly associated with elevated C-reactive protein levels in women, but not in men, in the Japanese general population. (2012)
  • Author(s): Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Tanaka F, Makita S, Nakamura M, Omama S, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Koyama T, Okayama A.
  • Journal Title: Journal of Psychosomatic Research Volume: 73 Pages: 225-231
  • Peer Reviewed
• [Journal Article] Comparison of the Incidence of Acute Decompensated Heart Failure Before and After the Major Tsunami in Northeast Japan (2012)
  • Author(s): Nakamura M, Tanaka F, Nakajima S,Honma M, Sakai T, Kawakami M, Endo H, Onodera M, Niiyama M, Komatsu T, Sakamaki K, Onoda T, Sakata K, Morino Y, Takahashi T, Makita S.
  • Journal Title: Am J Cardiol Volume: 110 Pages: 1856-1860
  • Peer Reviewed
• [Journal Article] Plasma B-Type Natriuretic Peptide is Useful for Cardiovascular Risk Assessment in Community-Based Diabetes Subjects -Comparison with Albuminuria. (2012)
  • Author(s): Onodera M, Nakamura M, Tanaka F, Takahashi T, Makita S, Ishisone T, Ishibashi Y, Itai K, Onoda T, Ohsawa M, Tanno K, Sakata K, Omama S, Ogasawara K, Ogawa A, Kuribayashi T, Sakamaki K, Okayama A.
  • Journal Title: International Heart Journal Volume: 53 Pages: 176-181
  • Peer Reviewed
• [Journal Article] Carotid plaque signal differences among four kinds of T1-weighted magnetic resonance imaging techniques: a histopathological correlation study (2012)
  • Author(s): Saito A, Sasaki M, Ogasawara K, Kobayashi M, Hitomi J, Narumi S, Ohba H, Yamaguchi M, Kudo K, Terayama Y.
  • Journal Title: Neuroradiology Volume: 54(11) Pages: 1187-1194
  • Peer Reviewed
• [Journal Article] Sex-specific threshold levels of plasma B-type natriuretic Peptide for prediction of cardiovascular event risk in a Japanese population initially free of cardiovascular disease. (2011)
  • Author(s): Nakamura M, Tanaka F, Takahashi T, Makita S, Ishisone T, Onodera M, Ishibashi Y, Itai K, Onoda T, Ohsawa M, Tanno K, Sakata K, Omama S, Ogasawara K, Ogawa A, Kuribayashi T, Okayama A.
  • Journal Title: Am J Cardiol Volume: 108 Pages: 1564-1569
  • Peer Reviewed
• [Journal Article] Serum low-density lipoprotein to high-density lipoprotein ratio as a predictor of future acute myocardial infarction among men in a 2.7-year cohort study of a Japanese northern rural population. (2011)
  • Author(s): Yokokawa H, Yasumura S, Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Kawamura K, Tanaka F, Yoshida Y, Nakamura M, Terayama Y, Ogawa A, Okayama A.
  • Journal Title: J Atheroscler Thromb Volume: 18(2) Pages: 89-98
  • Peer Reviewed
• [Journal Article] Seropositivity for Anti-HCV Core Antigen is Independently Associated With Increased All-Cause, Cardiovascular, and Liver Disease-Related Mortality in Hemodialysis Patients. (2011)
  • Author(s): Ohsawa M, Kato K, Tanno K, Itai K, Fujishima Y, Okayama A, Turin TC, Onoda T, Suzuki K, Nakamura M, Kawamura K, Akiba T, Sakata K, Fijioka T.
  • Journal Title: J Epidemiol Volume: 21(6) Pages: 491-499
  • Peer Reviewed
• [Journal Article] Comparison of low-density lipoprotein cholesterol concentrations measured by a direct homogeneous assay and by the Friedewald formula in a large community population (2010)
  • Author(s): Tanno K, Okamura T, Ohsawa M, Onoda T, Itai K, Sakata K, Nakamura N, Ogawa A, Kawamura K, Okayama A.
  • Journal Title: Clin Chim Acta Volume: 411(21-22) Pages: 1774-1780
  • Peer Reviewed
• [Journal Article] Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic syndrome in Japanese: the INTERLIPID Study (2010)
  • Author(s): Guo Z, Miura K, Turin TC, Hozawa A, Okuda N, Okamura T, Saitoh S, Sakata K, Nakagawa H, Okayama A, Yoshita K, Kadowaki T, Choudry SR, Nakamura Y, Rodriguez BL, Curb DJ, Elliot P, Stamler J, Ueshima H.
  • Journal Title: J Atheroscler Thromb Volume: 17(8) Pages: 777-784
  • Peer Reviewed
• [Journal Article] Altered carotid plaque signal among different repetition times on T1-weighted magnetic resonance plaque imaging with self-navigated radial-scan technique (2010)
  • Author(s): Narumi S, Sasaki M, Ohba H, Ogasawara K, Hitomi J, Mori K, OhuraK, Ono A, Terayama Y.
  • Journal Title: Neuroradiology Volume: 52(4) Pages: 285-290
  • Peer Reviewed