2012 Fiscal Year Final Research Report
Study on the evaluation of new biomarker's predictability of the onset of atherothrombosis
| Project/Area Number |
22590601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SAKATA Kiyomi 岩手医科大学, 医学部衛生学公衆衛生学講座, 教授 (50225794)
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| Co-Investigator(Kenkyū-buntansha) |
HITOMI Jiro (00218728)
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| Project Period (FY) |
2010 – 2012
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| Keywords | バイオマーカー / アテローム血栓症 |
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| Research Abstract |
Utilizing 468 preserved serums used for cohort studies whose initial follow-up was more than 6 years ago, serum levels of S100A12 protein and breakdown product of complement component C3a were measured, and comparison with their baseline results was made.Spearman’s coefficient of correlation of the serum concentration between S100A12 and C3a was 0.504 with p-value ≦ 0.0001. The correlation coefficients of S100A12 concentration with the level of triglyceride and that with leukocyte counts were significant. The correlation coefficients of the concentration of the breakdown product of C3a with HDL cholesterol level, leukocyte counts, blood sugar level, HbAlc, systolic blood pressure, diastolic blood pressure, and Body Mass Index were also significant. Neither existing condition nor incident stroke had significant association with S100A12 or C3a.
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Research Products
(13 results)
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[Journal Article] Influence of the Great East Japan Earthquake and Tsunami 2011 on Occuerrence of Cerebrovascular Diseases in Iwate,Japan.2013
Author(s)
Shinichi Omama, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Nakamura M, Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K.
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Journal Title
Stroke
Volume: 44(6)
Pages: 1518-1524
Peer Reviewed
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[Journal Article] Prediction of Carotid Plaque characteristics using non-gated MR imaging: correlation with endoarterectomy specimens.2013
Author(s)
Narumi S, Sakaki M, Ohba H, Ogasawara K, Kobayashi M, Hitomi J, Mori K, Ohura K, Yamaguchi M, Kudo K, Terayama Y
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Journal Title
Am J Neuroradiol
Volume: 34(1)
Pages: 191-197
Peer Reviewed
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[Journal Article] Influence of mild-to-moderate alcohol consumption on cardiovascular diseases in men from the general population2012
Author(s)
Makita S, Onoda T, Ohsawa M, Tanaka F, Segawa T, Takahashi T, Satoh K, Itai K, Tanno K, Sakata K, Omama S, Yoshida YIshibashi Y, Koyama T, Kuribayashi T, Ogasawara K, Ogawa A, Okayama A, Nakamura M.
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Journal Title
Atherosclerosis
Volume: 224
Pages: 222-227
Peer Reviewed
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[Journal Article] Poor self-rated health is significantly associated with elevated C-reactive protein levels in women, but not in men, in the Japanese general population.2012
Author(s)
Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Tanaka F, Makita S, Nakamura M, Omama S, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Koyama T, Okayama A.
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Journal Title
Journal of Psychosomatic Research
Volume: 73
Pages: 225-231
Peer Reviewed
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[Journal Article] Comparison of the Incidence of Acute Decompensated Heart Failure Before and After the Major Tsunami in Northeast Japan2012
Author(s)
Nakamura M, Tanaka F, Nakajima S,Honma M, Sakai T, Kawakami M, Endo H, Onodera M, Niiyama M, Komatsu T, Sakamaki K, Onoda T, Sakata K, Morino Y, Takahashi T, Makita S.
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Journal Title
Am J Cardiol
Volume: 110
Pages: 1856-1860
Peer Reviewed
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[Journal Article] Plasma B-Type Natriuretic Peptide is Useful for Cardiovascular Risk Assessment in Community-Based Diabetes Subjects -Comparison with Albuminuria.2012
Author(s)
Onodera M, Nakamura M, Tanaka F, Takahashi T, Makita S, Ishisone T, Ishibashi Y, Itai K, Onoda T, Ohsawa M, Tanno K, Sakata K, Omama S, Ogasawara K, Ogawa A, Kuribayashi T, Sakamaki K, Okayama A.
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Journal Title
International Heart Journal
Volume: 53
Pages: 176-181
Peer Reviewed
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[Journal Article] Sex-specific threshold levels of plasma B-type natriuretic Peptide for prediction of cardiovascular event risk in a Japanese population initially free of cardiovascular disease.2011
Author(s)
Nakamura M, Tanaka F, Takahashi T, Makita S, Ishisone T, Onodera M, Ishibashi Y, Itai K, Onoda T, Ohsawa M, Tanno K, Sakata K, Omama S, Ogasawara K, Ogawa A, Kuribayashi T, Okayama A.
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Journal Title
Am J Cardiol
Volume: 108
Pages: 1564-1569
Peer Reviewed
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[Journal Article] Serum low-density lipoprotein to high-density lipoprotein ratio as a predictor of future acute myocardial infarction among men in a 2.7-year cohort study of a Japanese northern rural population.2011
Author(s)
Yokokawa H, Yasumura S, Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Kawamura K, Tanaka F, Yoshida Y, Nakamura M, Terayama Y, Ogawa A, Okayama A.
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Journal Title
J Atheroscler Thromb
Volume: 18(2)
Pages: 89-98
Peer Reviewed
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[Journal Article] Seropositivity for Anti-HCV Core Antigen is Independently Associated With Increased All-Cause, Cardiovascular, and Liver Disease-Related Mortality in Hemodialysis Patients.2011
Author(s)
Ohsawa M, Kato K, Tanno K, Itai K, Fujishima Y, Okayama A, Turin TC, Onoda T, Suzuki K, Nakamura M, Kawamura K, Akiba T, Sakata K, Fijioka T.
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Journal Title
J Epidemiol
Volume: 21(6)
Pages: 491-499
Peer Reviewed
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[Journal Article] Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic syndrome in Japanese: the INTERLIPID Study2010
Author(s)
Guo Z, Miura K, Turin TC, Hozawa A, Okuda N, Okamura T, Saitoh S, Sakata K, Nakagawa H, Okayama A, Yoshita K, Kadowaki T, Choudry SR, Nakamura Y, Rodriguez BL, Curb DJ, Elliot P, Stamler J, Ueshima H.
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Journal Title
J Atheroscler Thromb
Volume: 17(8)
Pages: 777-784
Peer Reviewed
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