2012 Fiscal Year Final Research Report
The release of formaldehyde upon decomposition of preservative substance in the cosmetics
| Project/Area Number |
22590624
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Osaka Prefectural Institute of Public Health |
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Principal Investigator |
KAJIMURA Keiji 大阪府立公衆衛生研究所, 衛生化学部, 課長 (40250336)
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| Co-Investigator(Kenkyū-buntansha) |
DOI Takahiro 大阪府立公衆衛生研究所, 衛生化学部 (90516767)
TAGAMI Takaomi 大阪府立公衆衛生研究所, 衛生化学部 (00321943)
ASADA Akiko 大阪府立公衆衛生研究所, 衛生化学部 (80622753)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 香粧品 / ホルムアルデヒド / 防腐剤 / 分解挙動 / 抗菌活性 |
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| Research Abstract |
The release of formaldehyde (FA) due to imidazolidinyl urea decomposition was investigated. The release of FA was dependent on pH value and temperature. The release was markedly increased in a highly alkaline buffer compared with that in an acidic buffer. Diazolidinyl urea (DU) was decomposed to two compounds in most of the cosmetic samples tested. To test the contact sensitivity of the DU present in cosmetics, their concentrations should be evaluated.Quaternium-15(QN) and its decomposition products, including FA, play a major role in the preservative effect of cosmetics containing QN, and this effect was maintained at a virtually constant level for a long period.
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