2012 Fiscal Year Final Research Report
Connexin-43 based hemi-channel contributes to the propagation of μ-calpain mediated neuronal death in rat brain cortex
| Project/Area Number |
22590628
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | National Defense Medical College (2011-2012)
The University of Tokyo (2010) |
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Principal Investigator |
HARADA Kazuki 防衛医科大学校, 医学教育部医学科専門課程, 准教授 (00253146)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIDA Ken-ichi 東京大学, 医学(系)研究科(研究院), 教授 (40166947)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 神経細胞死 / 皮質層状壊死 / ヘミチャンネル / アストログリア / カルパイン / コネクシン43 |
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| Research Abstract |
We examined the contribution of GJ or HC on astrocytes or neurons to TBI spreading in a stab wound model in the rat cortex, and we demonstrated the importance of Cx43-based HC in the spread of μ-calpain-dependent neuronal death.
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Research Products
(1 results)
