2012 Fiscal Year Final Research Report
Determination of the infiltration of neutrophils into organs resulting from repetitive injuries, and development of diagnostic methodsfor the physical abuse
| Project/Area Number |
22590638
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
OGATA Mamoru 鹿児島大学, 大学院・医歯学総合研究科, 教授 (10152373)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Takahito 鹿児島大学, 大学院・医歯学総合研究科, 講師 (40512497)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 法医病理学 / 児童虐待 / 高齢者虐待 / 好中球 / ミエロパーオキシダーゼ / 炎症性サイトカイン / 好中球エラスターゼ / 多臓器不全 |
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| Research Abstract |
We investigated neutrophil infiltration into several organs in cases of child and elder physical abuse using immunohistochemistry for myeloperoxidase, a marker for primed neutrophil, P-selectin, anadhesion molecule, and interleukin-8, a chemotactic factor, and indicated that these analyses may represent supportive diagnostic methods for the physical abuse of the child and elderly. We also indicated that infiltrating primed neutrophils released elastase, a cytotoxic mediator, and suggested that patients with physical abuse may be in a primed stage of multiple organ failure.
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