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2013 Fiscal Year Final Research Report

Establishment of forensic autopsy diagnosis and severity evaluation criteria of post-traumatic shock and systemic inflammatory response syndrome

Research Project

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Project/Area Number 22590642
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionOsaka City University

Principal Investigator

MAEDA Hitoshi  大阪市立大学, 医学(系)研究科(研究院), 教授 (20135049)

Co-Investigator(Kenkyū-buntansha) MICHIUE Tomomi  大阪市立大学, 大学院医学研究科, 講師 (00529240)
ISHIKAWA Takaki  鳥取大学, 医学部, 教授 (50381984)
Project Period (FY) 2010-04-01 – 2014-03-31
Keywords法医学 / 外傷性ショック / 全身性炎症反応症候群 / 多臓器障害病態生化学 / 分子生化学
Research Abstract

Major issues in forensic autopsy include the analysis of a causal relationship between trauma and fatal outcome, which requires objective diagnostic evidence to support or supplement circumstantial evidence and clinical records. In conventional morphological pathology, however, it is difficult to detect functional deterioration in the death process and assess the findings with relevance to clinical findings. Therefore, the present study project comprehensively analyzed the pathophysiology after trauma using pathological, biochemical, molecular biological and immunohistochemical findings in routine casework to prepare criteria for autopsy diagnosis and severity evaluation of post-traumatic shock and systemic inflammatory response syndrome (SIRS), followed by assessing the validity of these criteria. These analyses provided objective criteria for assessment of acute responses in fatal traumas, subacute shock, and protracted shock, involving SIRS, multiple organ dysfunction and sepsis.

  • Research Products

    (16 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (3 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Forensic molecular pathology : Its impact on routine work2014

    • Author(s)
      Maeda H, Ishikawa T, Michiue T
    • Journal Title

      education and training

      Volume: 16 (Tokyo) Pages: 61-69

    • Peer Reviewed
  • [Journal Article] Comprehensive evaluation of peri- cardial biochemical markers in death in- vestigation2013

    • Author(s)
      Kawamoto O, Michiue T, Ishikawa T, Maeda H
    • Journal Title

      Forensic Sci Int

      Volume: 224 Pages: 73-79

    • DOI

      10.1016/j.forsciint.2012.10.03

    • Peer Reviewed
  • [Journal Article] Molecular pathology of brain edema after severe burns in forensic autopsy cases with special regard to the importance of reference gene selection2013

    • Author(s)
      Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H
    • Journal Title

      Int J Legal Med

      Volume: 127 Pages: 887-889

    • DOI

      10.1007/s00414-013-0868-x

    • Peer Reviewed
  • [Journal Article] Quantitative analysis of pulmonary pathophysiology using post- mortem computed tomography with regard to the cause of death2012

    • Author(s)
      Michiue T, Sakurai T, Ishikawa T, Oritani S, Maeda H
    • Journal Title

      Forensic Sci Int

      Volume: 220 Pages: 232-238

    • DOI

      10.1016/j.forsciint.2012.03.007

    • Peer Reviewed
  • [Journal Article] Pathophysiology of sudden cardiac death as demonstrated by molecular pathology of natriuretic peptides in the myocardium2012

    • Author(s)
      Chen JH, Michiue T, Ishikawa T, Maeda H
    • Journal Title

      Forensic Sci Int

      Volume: 223 Pages: 342-348

    • DOI

      10.1016/j.forsciint.2012.10.018

    • Peer Reviewed
  • [Journal Article] Forensic biochemistry for functional in- vestigation of death : Concept and prac- tical application2011

    • Author(s)
      Maeda H, Ishikawa T, Michiue T
    • Journal Title

      Leg Med

      Volume: 13 (Tokyo) Pages: 55-67

    • DOI

      10.1016/j.legalmed.2010.12.005

    • Peer Reviewed
  • [Journal Article] Postmortem serum erythropoietin level as a marker of sur- vival time in injury deaths2010

    • Author(s)
      Quan L, Zhu BL, Ishikawa T, Michiue T, Zhao D, Ogawa M, Maeda H
    • Journal Title

      Forensic Sci Int

      Volume: 200 Pages: 117-122

    • DOI

      10.1016/j.forsciint.2010.03.040

    • Peer Reviewed
  • [Journal Article] Forensic molecular pathology of violent deaths2010

    • Author(s)
      Maeda H, Zhu BL, Ishikawa T, Michiue T
    • Journal Title

      Forensic Sci Int

      Volume: 203 Pages: 83-92

    • DOI

      10.1016/j.forsciint.2010.07.024

    • Peer Reviewed
  • [Presentation] Postmortem CT morphometry of great vessels with re- gard to the cause of death for investiga- ting terminal circulatory function in forensic autopsy2013

    • Author(s)
      Sogawa N, Michiue T, Ishikawa T, Kawamoto O, Oritani S, Maeda H
    • Organizer
      92. Jahrestagung der Deutschen Gesellschaft für Rechtsmedizin
    • Place of Presentation
      Saarbrücken. Rechts- medizin (2013; 23:329)
    • Year and Date
      20130917-21
  • [Presentation] Myocardial toxicity of drugs as demon- strated by molecular pathology of natri- uretic peptides in the myocardium : a comparison of fatal methamphetamine and sedative-hypnotic abuse2012

    • Author(s)
      Maeda H, Chen JH, Michiue T, Ishikawa T
    • Organizer
      The 50th Annual Meeting of the International Association of Forensic Toxicologists
    • Place of Presentation
      Hamamatsu. Abstracts (p.113)
    • Year and Date
      20120603-08
  • [Presentation] Coordination of forensic autopsy laboratory system to visualize the pathophysiology of death : updated concept and routine casework2011

    • Author(s)
      Maeda H
    • Organizer
      8th International Symposium on Advances in Legal Medicine
    • Place of Presentation
      Frankfurt/M. Rechts- medizin (21:342)
    • Year and Date
      20110926-30
  • [Book] Systemic response to Trauma. J Siegel, P Saukko Eds. Ency- clopedia of Forensic Sciences, 2nd Ed2013

    • Author(s)
      Ishikawa T, Maeda H
    • Total Pages
      47- 53, (vol.3)
    • Publisher
      Amsterdam : Elsevier
  • [Book] Hyperthermia and hypothermia. J Siegel, P Saukko Eds. Ency- clopedia of Forensic Sciences, 2nd Ed2013

    • Author(s)
      Ishikawa T, Maeda H
    • Total Pages
      139 -145, (vol.3)
    • Publisher
      Amsterdam : Elsevier
  • [Book] Immuno- histochemistry of neuronal apoptosis in fatal traumas : The contribution of foren- sic molecular pathology in medical science2012

    • Author(s)
      Wang Q, Michiue T, Maeda H
    • Total Pages
      247-276
    • Publisher
      T Ntuli Ed. Apoptosis and Medicine. Rijeka: InTech
  • [Remarks] 大阪市立大学大学院医学研究科法医学教室

    • URL

      http://www.med.osaka-cu.ac.jp/legalmed/

  • [Remarks] 鳥取大学医学部医学科法医学分野

    • URL

      http://www.med.tottori-u.ac.jp/legalmed/

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Published: 2015-07-16  

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