2012 Fiscal Year Final Research Report
Effect of stress on methamphetamine intoxication- involvement of stress protein
| Project/Area Number |
22590644
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATSUYAMA Hironobu 川崎医科大学, 医学部, 教授 (00289175)
WATANABE Yoko 川崎医科大学, 医学部, 講師 (70135945)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 覚醒剤 / ストレス / 中毒 |
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| Research Abstract |
In the present study, we assessed the effects of stress on intoxication due to methamphetamine (METH) in mice. Mice were injected with 30 mg/kg i.p. (the acute study) or 10 mg/kg i.p three times per week (the chronic study). The histological findings indicated that METH induced more deleterious effects in the myocardial tissues during acute and chronic administrations when under stress conditions. Heat shock proteins (Hsps) played a critical role in the acute phase, while numerous genes, including anti-oxidant, anti-apoptotic genes played significant roles in the chronic phase. We obtained a significant impact of glucocorticoid receptor (GR) gene polymorphism on cardiac injury and 8-OHdG in urine samples. Pituitary glands were also affected by METH under stress. Now, we are investigating the effect of METH and/or stress on bone mineral density and neuronal cell reactions.
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