2013 Fiscal Year Final Research Report
Conditioning and Extinction Learning of Visceral Pain in Human
| Project/Area Number |
22590646
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
KANO Michiko 東北大学, 医学(系)研究科(研究院), 助教 (20344658)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDO Shin 東北大学, 大学院医学系研究科, 教授 (80199249)
KANAZAWA Motoyori 東北大学, 大学院医学系研究科, 講師 (70323003)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 内臓痛 / 条件付け / ニューロイメージング / 消去 / 回復 / 前頭前野 / ペインマトリックス |
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| Research Abstract |
Learning and memory mechanisms involved in the processing of internal bodily sensations may be relevant for elucidating the pathophysiology of functional somatic diseases. We investigated brain processing during associative learning and modification of the learned response to visceral pain using a classical conditioning paradigm and mechanical oesophageal stimulation. Conditioning responses (CR) using visceral pain produced a neural response in the absence of physical visceral pain similar to that occurs during actual visceral pain. Frontal cortex activity may play an important role in extinction learning to regulate acquired CR. The activation in the hippocampus may be associated with memory retrieval of CR after extinction. These findings elucidate the brain mechanism underlying how aversive memory of visceral pain is modified depending on circumstantial change.
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[Journal Article] Psychophysiological responses to pain identify reproducible human clusters2013
Author(s)
Farmer AD, Coen SJ, Kano M, Paine PA, Shwahdi M, Jafari J, Kishor J, Worthen SF, Rossiter HE, Kumari V, Williams SC, Brammer M, Giampietro VP, Droney J, Riley J, Furlong PL, Knowles CH, Lightman SL, Aziz Q
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Journal Title
Pain
Volume: 154(11)
Pages: 2266-76
DOI
Peer Reviewed
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