2012 Fiscal Year Final Research Report

Protective effect of Kampo medicine on vascular endothelial functionin patients with metabolic syndrome

Research Project

Project/Area Number	22590649
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General internal medicine (including Psychosomatic medicine)
Research Institution	University of Toyama
Principal Investigator	SHIMADA Yutaka 富山大学, 大学院・医学薬学研究部(医学), 教授 (80251891)
Co-Investigator(Renkei-kenkyūsha)	HIKIAMI Hiroaki 富山大学, 大学院・医学薬学研究部(医学), 准教授 (70345586) FUJIMOTO Makoto 富山大学, 附属病院, 講師 (30377337) GOTO Hirozo 富山大学, 大学院・医学薬学研究部(医学), 准教授 (40313598)
Project Period (FY)	2010 – 2012
Keywords	東洋医学
Research Abstract	We clarified the improvement effect of keishibukuryogan, a traditional Japanese （Kampo) formula, on endothelial function in patients with metabolic syndrome-related factors by controlled clinical trial with cross-over design. In 49 patients who completed all the tests, the index for the evaluation of endothelial function （L_RHI) assessed by Endo-PAT2000 increased significantly, and the serum non-esterified fatty acid （NEFA), malondialdehyde （MDA) and soluble vascular cell adhesion molecule-1（sVCAM-1) decreased significantly after 4 weeks of KBG-treatment period, and the changes of L_RHI, NEFA and MDA in the treatment period were significantly different from those in the control period

(2 results)