2012 Fiscal Year Final Research Report
Protective effect of Kampo medicine on vascular endothelial functionin patients with metabolic syndrome
| Project/Area Number |
22590649
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine (including Psychosomatic medicine)
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
SHIMADA Yutaka 富山大学, 大学院・医学薬学研究部(医学), 教授 (80251891)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIKIAMI Hiroaki 富山大学, 大学院・医学薬学研究部(医学), 准教授 (70345586)
FUJIMOTO Makoto 富山大学, 附属病院, 講師 (30377337)
GOTO Hirozo 富山大学, 大学院・医学薬学研究部(医学), 准教授 (40313598)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 東洋医学 |
|---|
| Research Abstract |
We clarified the improvement effect of keishibukuryogan, a traditional Japanese （Kampo) formula, on endothelial function in patients with metabolic syndrome-related factors by controlled clinical trial with cross-over design. In 49 patients who completed all the tests, the index for the evaluation of endothelial function （L_RHI) assessed by Endo-PAT2000 increased significantly, and the serum non-esterified fatty acid （NEFA), malondialdehyde （MDA) and soluble vascular cell adhesion molecule-1（sVCAM-1) decreased significantly after 4 weeks of KBG-treatment period, and the changes of L_RHI, NEFA and MDA in the treatment period were significantly different from those in the control period
|
