• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Protective effect of Kampo medicine on vascular endothelial functionin patients with metabolic syndrome

Research Project

  • PDF
Project/Area Number 22590649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionUniversity of Toyama

Principal Investigator

SHIMADA Yutaka  富山大学, 大学院・医学薬学研究部(医学), 教授 (80251891)

Co-Investigator(Renkei-kenkyūsha) HIKIAMI Hiroaki  富山大学, 大学院・医学薬学研究部(医学), 准教授 (70345586)
FUJIMOTO Makoto  富山大学, 附属病院, 講師 (30377337)
GOTO Hirozo  富山大学, 大学院・医学薬学研究部(医学), 准教授 (40313598)
Project Period (FY) 2010 – 2012
Keywords東洋医学
Research Abstract

We clarified the improvement effect of keishibukuryogan, a traditional Japanese (Kampo) formula, on endothelial function in patients with metabolic syndrome-related factors by controlled clinical trial with cross-over design. In 49 patients who completed all the tests, the index for the evaluation of endothelial function (L_RHI) assessed by Endo-PAT2000 increased significantly, and the serum non-esterified fatty acid (NEFA), malondialdehyde (MDA) and soluble vascular cell adhesion molecule-1(sVCAM-1) decreased significantly after 4 weeks of KBG-treatment period, and the changes of L_RHI, NEFA and MDA in the treatment period were significantly different from those in the control period

  • Research Products

    (2 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Effect of keishibukuryogan on endothelial function in patients with at least one component of the diagnostic criteria for metabolic syndrome: a controlled clinical trial with cross-over design2012

    • Author(s)
      Yutaka Nagata, Hirozo Goto, Hiroaki Hikiami, Tatsuya Nogami, Makoto Fujimoto, Naotoshi Shibahara, Yutaka Shimada
    • Journal Title

      Evidence-based Complementary and Alternative Medicine

      Volume: Volume 2012 Pages: 10

    • DOI

      DOI:10.1155/2012/359282

    • Peer Reviewed
  • [Presentation] メタボリックシンドローム関連因子を有する患者の血管内皮機能に及ぼす桂枝茯苓丸の効果:比較臨床試験2012

    • Author(s)
      永田 豊, 後藤博三, 井上博喜, 野上達也, 藤本 誠, 引網宏彰, 柴原直利, 長坂和彦, 嶋田 豊
    • Organizer
      第29回和漢医薬学会学術大会
    • Place of Presentation
      東京.
    • Year and Date
      20120901-02

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi