2012 Fiscal Year Final Research Report
Both Herbal medicine Bofu-tsusho-san (TJ-62) and Dai-saiko-to (TJ-8) prevent liver fibrosis and hepatocarcinogenesis in rat liver cirrhosis.
| Project/Area Number |
22590657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Yamaguchi University |
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Principal Investigator |
UCHIDA Kouichi 山口大学, 医学部附属病院, 講師 (80397992)
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| Co-Investigator(Kenkyū-buntansha) |
TERAI Syuji 山口大学, 大学院・医学系研究科, 准教授 (00332809)
YAMAMOTO Naoki 山口大学, 大学教育機構, 講師 (90448283)
TAKAMI Taro 山口大学, 大学院・医学系研究科, 講師 (60511251)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 漢方薬 / 非アルコール性脂肪肝炎 / 肝線維化. |
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| Research Abstract |
The aim of this study was to investigate whether both Dai-saiko-to (TJ-8) and Bofu-tsusho-san (TJ-62) have any influence on the development of preneoplastic lesions as well as liver fibrosis.Results: After 12 weeks, both TJ-8 and TJ-62 prevented fibrosis in a dose-dependent manner by Azan, Sirius Red, αSMA expression (p < 0.05). Hydroxyproline level in liver was decreased (mean value: CDAA+TJ-8 6.3 vs CDAA only 13.4 umol/Wg P
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