2013 Fiscal Year Final Research Report
Elucidation of anti-metabolic syndrome effects by San'oshashinto
| Project/Area Number |
22590660
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Toshihiro 琉球大学, 大学院医学研究科, 助教 (50244330)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 漢方薬 / 東洋医学 / 虚血性心疾患 / メタボリックシンドローム / 薬理学 / 循環器学 |
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| Research Abstract |
San'oshashinto is one of the herbal medicines used for climacteric disorder. In ovariectomized female rats as a model of menopausal women, San'oshashinto reduces increased total cholesterol level and postprandial hyperglycemia, and so prevents the development of metabolic syndrome (MetS). Furthermore, San'oshashinto improves cardiac ischemia reperfusion injury that is the myocardial damage caused when blood supply returns to the tissue after a period of ischemia. (Cardiac ischemia reperfusion injury may develop as the result of the onset of MetS.) Emodin, one of the ingredients of San'oshashinto, participates in these beneficial effects. Especially, emodin's estrogen-like effect is involved in the card ioprotective effects on ischemia reperfusion injury.
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[Journal Article] Long-Term Treatment With San'o-Shashin-To, a Kampo Medicine, Markedly Ameliorates Cardiac Ischemia-Reperfusion Injury in Ovariectomized Rats via the Redox-Dependent Mechanism2013
Author(s)
Mayuko Sakanashi, Toshihiro Matsuzaki, Katsuhiko Noguchi, Junko Nakasone, Makiko Sakanashi, Taro Uchida, Mika Kina-Tanada, Haruaki Kubota, Kumiko Arakaki, Akihide Tanimoto, Nobuyuki Yanagihara, Matao Sakanashi, Yusuke Ohya , Hiroaki Masuzaki, Shogo Ishiuchi, Kazuhiro Sugahara, Masato Tsutsui
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Journal Title
Circulation Journal
Volume: vol. 77, No.7
Pages: 1827-37
DOI
Peer Reviewed
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