2012 Fiscal Year Final Research Report
Contribution of stress and arteriolosclerosis to vascular dementia and chronic renal disease in the patients with hypertension
| Project/Area Number |
22590662
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
HANO Takuzo 和歌山県立医科大学, 医学部, 教授 (90156381)
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| Co-Investigator(Kenkyū-buntansha) |
KAWABE Tetsuya 和歌山県立医科大学, 医学部, 助教 (60508034)
UEYAMA Takashi 和歌山県立医科大学, 医学部, 准教授 (50264875)
MIZOKOSHI Masato 和歌山県立医科大学, 医学部, 講師 (90254531)
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| Research Collaborator |
IWANE Naomi
MIYOSHI Noriko
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| Project Period (FY) |
2010 – 2012
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| Keywords | 認知機能 / 腎障害 / ストレス / 微小血流 / 高血圧 |
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| Research Abstract |
Aim was to know the contribution of stress on cognitive function and renal medullar function through altered microcirculation. Stress induced cognitive dysfunction in rats and taurine improved this in hypertensive rats. Stress showed no effec ts on blood flow around amygdala. Renal medulla blood flow was maintained by NO after renal nerve stimulation but significantly reduced in hypertensive rats. Senescent endothelial progenitor cell was increased in hypertensive rats and improved by chronic taurine treatment.
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