2012 Fiscal Year Final Research Report
Preventive effects of nitrate against ischemic brain injury
| Project/Area Number |
22590663
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Josai University |
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Principal Investigator |
OKAZAKI Mari 城西大学, 薬学部, 准教授 (50272901)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Hirokazu 城西大学, 薬学部, 助手 (80582238)
HIBINO Yasuhide 城西大学, 薬学部, 教授 (10189805)
KAMIUCHI Shinya 城西大学, 薬学部, 助教 (80433647)
IWATA Naohiro 城西大学, 薬学部, 助手 (50552759)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 亜硝酸塩 / 虚血性脳障害 / 一酸化窒素 / 嚥下障害 / ラット |
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| Research Abstract |
In the present study, we investigated whether nitrite exerts protective effects against ischemic brain injury induced by middle cerebral artery occlusion following reperfusion (MCAO/Re) or by chronic cerebral hypoperfusion (2VO)in rats. We found that infract volume, edema, and the number of apoptotic cells in the rat brain determined after MCAO/Re were reduced by intravenous injection of nitrite. Chronic supplementation of nitrite improved the swallowing reflex in the 2VO rats. These results suggest that dietary supplementation of nitrite may relieve the ischemic brain injury and post-stroke dysphagia.
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