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2012 Fiscal Year Final Research Report

Brain regions that are involved in psychogenic fever

Research Project

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Project/Area Number 22590671
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

HAYASHI Haruo  産業医科大学, 医学部, 非常勤医師 (80569161)

Co-Investigator(Kenkyū-buntansha) OKA Takakazu  九州大学, 医学(系)研究科(研究院), 准教授 (60291514)
Project Period (FY) 2010 – 2012
Keywords心因性発熱 / ストレス性高体温症 / 慢性疲労症候群 / 不明熱
Research Abstract

We investigated if stress-induced hyperthermia (SIH) is nlediated by the activation of the vesicular glutamate transporter 3 (VGLUT3)-positive sympathetic premotor neurons in the rostral medullary raphe region in a similar manner as infection/inflammation-induced fever. Rats exposed to social defeated stress exhibited a rapid increase in abdominal temperature and induced Fos, a marker of neuronal activation, in the VGLUT3-expressing neurons in the rostral medullary raphe region. Pretreatment with diazepam attenuated both SIH and Fos expression in these regions. These findings suggest that SIH is mediated by the VGLUT3-positive sympathetic premotor neurons in the rostral medullary raphe region.

  • Research Products

    (27 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (18 results) Remarks (1 results)

  • [Journal Article] Psychological stress contributed to the development of low-grade fever in a patient with chronic fatigue syndrome:acase report2013

    • Author(s)
      Oka T, Kanemitsu Y, Sudo N, Hayashi H, Oka K
    • Journal Title

      Biopsychosoc Med

      Volume: 7(1) Pages: 7

    • DOI

      DOI:10.1186/1751-0759-7-7

    • Peer Reviewed
  • [Journal Article] 心因性発熱の治療-「整える療法」の紹介を含めて-2013

    • Author(s)
      岡孝和
    • Journal Title

      心身医

      Volume: 52(9) Pages: 845-856

  • [Journal Article] 慢性疲労症候群患者にみられるストレス性高体温症とその治療2012

    • Author(s)
      岡孝和
    • Journal Title

      日本疲労学会誌

      Volume: 7(2) Pages: 42-48

  • [Journal Article] Mechanisms of psychogenic fever2012

    • Author(s)
      Oka T, Oka K
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: (3) Pages: 3-17

    • DOI

      DOI10.3233/NIB-2012-OllO30

    • Peer Reviewed
  • [Journal Article] ストレスと体温調節反応-心因性発熱の機序に関する最近の進歩-2011

    • Author(s)
      岡孝和
    • Journal Title

      自律神経

      Volume: 48 Pages: 196-198

  • [Journal Article] 熱(心因性発熱)がおさまらない子ども2011

    • Author(s)
      岡孝和
    • Journal Title

      教育と医学

      Volume: 59 Pages: 194-200

  • [Journal Article] Social defeat stress induces hyperthermia through activation of thermoregulatory symPathetic premotor neurons in the medullary raphe region2011

    • Author(s)
      Lkhagvasuren B, Nakamura Y, Oka T, Sudo N, Nakamura K
    • Journal Title

      Eur J Neurosci

      Volume: 34(9) Pages: 1442-52

    • DOI

      DOI:10.1111/j.1460-9568.2011.07863. x

    • Peer Reviewed
  • [Journal Article] Repeated social defeat stress induces chronic hyperthermia in rats2010

    • Author(s)
      Hayashida S, Oka T, Mera T, Tsuji S
    • Journal Title

      Physiol Behav

      Volume: 101(1) Pages: 124-31

    • DOI

      DOI:10.1016/j. physbeh.2010.04.027

    • Peer Reviewed
  • [Presentation] Psychosocial stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe2012

    • Author(s)
      Battuvshin Lkhagvasuren, Yoshiko Nakamura, Takakazu Oka, Nobuyuki Sudo, Kazuhiro Nakamura
    • Organizer
      15th Congress of Asian College of Psychosomatic Medicine
    • Place of Presentation
      Ulaanbaatar, Mongolia
    • Year and Date
      20120824-25
  • [Presentation] 心理的ストレスによる体温上昇には淡蒼縫線核交感神経プレモーターニューロンが関与する2012

    • Author(s)
      ルクババスレンバトトブシン、岡孝不口、須藤信行、中村和弘、中村佳子、榊青男
    • Organizer
      第17回日本心療内科学会総会・学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-11-17
  • [Presentation] Social defeat stress-induced hyperthermia is associated with neuronal activation of the dorsomedial hypothalamus2012

    • Author(s)
      Takakazu Oka, Battuvshin Lkhagvasuren, Yoshiko Nakamura, Haruo Hayashi, Kazuhiro Nakamura
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
  • [Presentation] ストレス性高体温には発熱と同様、淡蒼縫線核交感神経プレモーターニューロンが関与する2012

    • Author(s)
      岡孝和、ルクババスレン バトトプシン、須藤信行、林晴男、中村桂子、中村和弘
    • Organizer
      第8回日本疲労学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-02
  • [Presentation] ストレス性高体温には淡蒼縫線核交感神経プレモーターニューロンが関与する2012

    • Author(s)
      ルクババスレン バトトプシン、岡孝和、須藤信行、林晴男
    • Organizer
      第53回日本心身医学会総会学術講演会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-05-25
  • [Presentation] 慢性疲労症候群患者におけるストレス性高体温反応の機序に関する検討2012

    • Author(s)
      岡孝和、金光芳郎、条藤信行、林晴男
    • Organizer
      第53回日本心身医学会総会・学術講演会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-05-25
  • [Presentation] 心因性発熱、慢性疲労症候群でみられる微熱の機序と、その治療について(教育講演)2012

    • Author(s)
      岡孝和
    • Organizer
      第53回日本心身医学会総会・学術講演会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-05-25
  • [Presentation] Repeated social defeat stress induces chronic hyperthermia in rats2011

    • Author(s)
      Sota Hayashida, Takakazu Oka, Takashi Mera, Haruo Hayashi, Sadatoshi Tsuji
    • Organizer
      The 21st World Congress on Psychosomatic Medicine
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20111825-28
  • [Presentation] Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region in rats2011

    • Author(s)
      Takakazu Oka, Battuvshin Lkhagvasuren, Yoshiko Nakamura, Kazuhiro Nakamura
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-15
  • [Presentation] Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region2011

    • Author(s)
      Takakazu Oka, Battuvshin Lkhagvasuren, Yoshiko Nakamura, Kazuhiro Nakamura
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
  • [Presentation] 心因性発熱の自律神経機能2011

    • Author(s)
      岡孝和
    • Organizer
      第50回日本心身医学会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2011-02-05
  • [Presentation] ラットで繰り返す社会的敗北ストレスは慢性の高体温を生じる2010

    • Author(s)
      林田草太、米良貴嗣、岡孝和、辻貞俊
    • Organizer
      第15回日本心療内科学会総会・学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2010-11-20
  • [Presentation] Repeated psychosocial stress induces chronic hyperthermia in the rat2010

    • Author(s)
      Takakazu Oka, S・ta Hayashida, Takashi Mera, Sadatoshi Tsuji
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2010-11-16
  • [Presentation] ストレスと体温2010

    • Author(s)
      岡孝和
    • Organizer
      第63回日本自律神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-22
  • [Presentation] 抑肝散はストレス性発熱を抑制する2010

    • Author(s)
      米良貴嗣、林田草太、岡孝和、高橋昌稔、柴田達徳、林晴男、辻貞俊
    • Organizer
      第51回日本心身医学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-06-27
  • [Presentation] 繰り返す社会的敗北ストレスはラットで慢性高体温症を生じる2010

    • Author(s)
      岡孝和、林田草太、米良貴嗣、辻貞俊
    • Organizer
      第51回日本心身医学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-06-27
  • [Presentation] ストレス性微熱(心因性発熱)の病態と治療-フルボキサミンの有用性を含めて-2010

    • Author(s)
      岡孝和
    • Organizer
      第51回日本'L身医学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-06-26
  • [Presentation] Repeated social defeat stress induces chronic hyperthermia in rats2010

    • Author(s)
      Takakazu Oka, Sota Hayashida, Takashi Mera, Sadatoshi Tsuji
    • Organizer
      American Psychosomatic Society, 68th annual scientific meeting
    • Place of Presentation
      Portland, OR, USA
    • Year and Date
      2010-03-13
  • [Remarks]

    • URL

      http://okat. web. fc2. com/page02

URL: 

Published: 2014-08-29  

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