2012 Fiscal Year Final Research Report
Role of macrophage migration inhibitory factor in esophagitis and esophageal tumor
| Project/Area Number |
22590675
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHKAWARA Tatsuya 北海道大学, 大学院・薬学研究院, 研究員 (00374257)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 好酸球性食道炎 / マクロファージ遊走阻止因子 |
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| Research Abstract |
We basically investigated the role of macrophage migration inhibitory factor(MIF) in esophageal diseases. The expression of MIF protein in the esophagus of rats was less than that of stomach and intestine in rat. We developed MIF DNA vaccine, which is a novel MIF inhibitor, and this vaccine ameliorated the severity of intestinal inflammation in mice. In the study using MIF knockout mice, MIF did not affect the level of gastric acid-secretion in mice. MIF knockout mice were resistant to drug-induced gastrointestinal inflammation, partly via induction of heat shock protein. Treatment with MIF inhibitor suppressed eosinophil infiltrate in the esophagus of mice.
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