2012 Fiscal Year Final Research Report
Analysis of the mechanism of gastric tumorigenesis using mice with stomach-specific gene recombination
| Project/Area Number |
22590679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Yoshihiro 東京大学, 医学部附属病院, 助教 (10529192)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癌 / シグナル伝達 |
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| Research Abstract |
The aim of this study was to establish stomach-specific gene recombination mice for the research of gastric tumorigenesis. Using this model, we established highly reproducible gastric tumor model and analyzed the mechanism of carcinogenesis. We found several cytokines and intracellular kinases were involved in the gastric carcinogenesis. Role of each molecule was clarified using knockout mice and gastric cancer cell lines treated with siRNA and inhibitors.
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