2012 Fiscal Year Final Research Report
Characterization of bacterial biota in the distal esophagus of Japanese patients with reflux esophagitis and Barrett's esophagus
| Project/Area Number |
22590680
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya University |
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Principal Investigator |
ANDO Takafumi 名古屋大学, 医学系研究科, 准教授 (80378041)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Hidemi 名古屋大学, 大学院・医学系研究科, 教授 (10215501)
OHMIYA Naoki 名古屋大学, 医学部附属病院, 講師 (00335035)
WATANABE Osamu 名古屋大学, 医学部附属病院, 助教 (80378059)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 食道炎 / バレット食道 / 食道腺癌 / 食道下部細菌叢 / 16Sリボゾーム [〇!R]RNA / シークエンス解析 |
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| Research Abstract |
We investigated bacterial composition in the distal esophagus in subjects with a normal esophagus, reflux esophagitis, and Barrett’s esophagus. Biopsy specimens were obtained from the distal esophagus and used for histological examination and DNA extraction. Fragments of 16S rDNA genes were amplified by PCR using general bacterial primers, and bacterial populations were examined. Microbial communities differed among patients with a normal esophagus, reflux esophagitis and Barrett’s esophagus. From this study, we conclude that esophageal bacterial composition differs under conditions of normal esophagus, reflux esophagitis, and Barrett’s esophagus and Diverse bacterial communities may be associated with esophageal disease.
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Research Products
(4 results)
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[Presentation] Prophyylactic Helicobacter pylori eradication in the gastric remnant may be useful in preventing metachronous gastric carcinoma2012
Author(s)
Takafumi Ando, Masatoshi Sakakibara, Kazuhiro Ishiguro, Osamu Maeda, Osamu Watanabe, Toru Kamiya, Shunya Mimura, Masaki Ujihara, Yutaka Hirayama, Kazuhiro Morise, Keiko Maeda, Masanobu Matushita, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Naoki Ohmiya, Hidemi Goto
Organizer
International Ulcer Week 2012
Place of Presentation
Tokyo, Japan
Year and Date
20120700
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