Development of multi-modality circumferential sensor array andthe analysis of esophageal motility

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590683
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Shimane University
• Principal Investigator: KINOSHITA Yoshikazu 島根大学, 医学部, 教授 (30243306)
• Research Collaborator: AIMI Masahito 島根大学, 医学部, 医科医員 ; FUKAZAWA Kousuke 島根大学, 医学部, 医科医員 ; FURUTA Kenji 島根大学, 医学部, 講師 ; ADACHI Kyoichi 島根大学, 医学部, 教授 ; KITAGAKI Hajime 島根大学, 医学部, 教授
• Project Period (FY): 2010 – 2012
• Keywords: 胃食道逆流 / 逆流性食道炎 / 横隔膜 / pH

Research Abstract

We have developed a multi-modality circumferential sensor array with 8 pH and 8 pressure sensors arranged in 8 different directions for evaluating esophageal contraction and gastro-esophageal acid reflux at the esophago-gastric junction. We have also developed a morph metrical diagnosis on esophago-gastric junction with a 320 row CT. With these two methods, we have found that the gastro-esophageal reflux can be divided in two types. One of them is the volume reflux related with transient lower esophageal sphincter relaxation. This type of reflux is frequently accompanied by the secondly peristalsis with volume clearance. The other type of reflux is the creeping reflux caused by the small volume reflux that occurs mainly on the right anterior wall of the esophagus. Thisinformation found in this study facilitates the thorough understanding of the mechanism of gastro-esophageal reflux.

Research Products

• [Journal Article] Observations of acid reflux and motor function in distal esophagus using simultaneous measurements of intra-esophageal pH and pressure in 8 directions with novel sensor catheter -a feasibility study- (2013)
  • Author(s): Aimi M, Furuta K, Morita Y, Fukazawa K, Adachi K, Kinoshita Y
  • Journal Title: J. Neurogastroenterol Motil Volume: 19 Pages: 42-46
  • DOI: DOI:10.5056/jnm.2013.19.1.42.
  • Peer Reviewed
• [Journal Article] Radially asymmetric gastroesophageal acid reflux in the distal esophagus: Examinations with novel pH sensor catheter equipped with 8 pH sensors (2012)
  • Author(s): Ohara S, Furuta K, Adachi K, Shimura S, Fukazawa K, Aimi M, Okamoto E, Komazawa Y, Kinoshita Y
  • Journal Title: J. Gastroenterol Volume: 47 Pages: 1221-1227
  • DOI: DOI:10.1007/s00535-012-0595-y
  • Peer Reviewed
• [Journal Article] Effect of rekkunshito (TJ-43) on esophageal motor function and gastroesophageal reflux (2012)
  • Author(s): Morita T, Furuta K, Adachi K, Ohara S, Tanimura T, Koshino K, Uemura T, Naora K, Kinoshita Y
  • Journal Title: J. Neurogastroenterol Motil Volume: 18 Pages: 181-186
  • DOI: DOI:10.5056/jnm.2012.18.2.181
  • Peer Reviewed
• [Journal Article] Infuluence of full-body water immersion on esophageal motor function and intragastric pressure (2012)
  • Author(s): Aimi M, Furuta K, Saito T, Shimura S, Fukazawa K, Ohara S, Uno G, Tobita H, Adachi K, Kinoshita K
  • Journal Title: J Neurogastroenterol Motil Volume: 18 Pages: 194-199
  • DOI: DOI:10.5056/jnm.2012.18.2.194
  • Peer Reviewed
• [Journal Article] Relationship between kyphosis and Barrett's esophagus in Japanese patients (2011)
  • Author(s): Uno G, Amano Y, Yuki T, Oka A, Ishimura N, Ishihara S, Kinoshita Y
  • Journal Title: Int Med Volume: 50 Pages: 2725-2730
  • DOI: DOI:10.2169/internalmedicine.50.6179
  • Peer Reviewed
• [Journal Article] Effects of nizatidine and itopride hydrochloride on esophageal motor function (2011)
  • Author(s): Koshino K, Adachi K, Furuta K, Aimi M, Fukazawa K, Shimura S, Morita T, Nakata S, Ohara S, Tanimura T, Miki M, Kinoshita Y
  • Journal Title: Esophagus Volume: 8 Pages: 253-257
  • DOI: DOI:10.1007/s10388-011-0289-1
  • Peer Reviewed
• [Journal Article] Continuous imaging of esophago-gastric junction in patients with reflux esophagitis using 320-row area detector CT: a feasibility study
  • Author(s): Fukazawa K, Furuta K, Adachi K, Shimura S, Kamiyama K, Aimi M, Ohara S, Kajitani T, Tsurusaki M, Kitagaki H, Kinoshita Y
  • Journal Title: J. Gastroenterol Hepotal
  • DOI: DOI:10.1111/jgh.12267
  • Peer Reviewed