2012 Fiscal Year Final Research Report
Functional analysis of tight junction protein: claudins on the development and progression of gastric cancer
| Project/Area Number |
22590691
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATARI Jiro 兵庫医科大学, 医学部, 教授 (10311531)
MIWA Hirot 兵庫医科大学, 医学部, 教授 (80190833)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 上部消化管学(食道,胃,十二指腸) |
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| Research Abstract |
The morbidity of gastric cancer is still high in Japan, and it is know that Helicobacter pylori infection is involved in the development of gastric cancer. However, the incidence of gastric cancer in Helicobacter pylori infected people is a couple of %. We focused on tight junction proteins as the factor related to the development of gastric cancer and the malignancy. Down-regulation of claudin-3 was associated with proliferative potential of gastric cancer cells. Furthermore, down-regulation of claudin-18 at the invasive front of gastric cancer was associated with the proliferative and invasivepotential, suggesting that they have pivotal roles in gastric cancer progression.
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[Journal Article] REG Iα is a biomarker for predicting response to chemotherapy S-1 plus cisplatin in patients with unresectab le stage IV gastric cancer.2013
Author(s)
Sekikawa A, Fukui H, Zhang X, Maruo T, Tsumura T, Okabe Y, Wakasa T, Osaki Y, Chiba T, Tomita T, Oshima T, Watari J, Miwa H.
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Journal Title
Br J Cancer.
Volume: 108(2)
Pages: 395-401
DOI
Peer Reviewed
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[Journal Article] Biomarkers predicting development of metachronous gastric cancer after endoscopic resection: An analysis of molecular pathology of Helicobacter pylori eradication.2012
Author(s)
Watari J, Moriichi K, Tanabe H, Kashima S, Nomura Y, Fujiya M, Tomita T, Oshima T, Fukui H, Miwa H, Das KM, Kohgo Y.
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Journal Title
Int J Cancer.
Volume: 15;130(10)
Pages: 2349-58
DOI
Peer Reviewed
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[Presentation] Watari J, Fujimori T, Miwa H. Groαpromotes invasion of gastric cancer cells.2013
Author(s)
Fukui H, Zhang X, Sun C, Yamasaki T, Kondo T, Ikehara H, Tomita T, Oshima T
Organizer
Sa1719 (Digestive Disease Week
Place of Presentation
Orlando, Florida, USA)
Year and Date
2013-05-18
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[Presentation] Involvement of IL-22 signaling in gastric cancer cell invasion.2012
Author(s)
Fukui H, Zhang X, Toyoshima F, TomitaT, Oshima T, Watari J, Imura J, Fujimori T, Matsumoto T, Miwa H.
Organizer
Su1840 (Digestive Disease Week
Place of Presentation
San Diego, California, USA)
Year and Date
2012-05-22
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[Presentation] Down-regulation of submucosal claudin-18 at the invasivefront is associated with proliferative potential of submucosal gastric cancer.2011
Author(s)
Okugawa T, Oshima T, Morita T, SakuraiJ, Tanaka J, Tomita T, Fukui H, Watari J, Matsumoto T, Miwa H.
Organizer
Sa1907 (Digestive Disease Week
Place of Presentation
Chicago, Illinois, USA)
Year and Date
2011-05-07
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[Presentation] 胃粘膜内癌におけるクローディンの発現と増殖能は相関する.奥川卓也,大島忠之2010
Author(s)
Chen Xin,神谷紀子,豊島史彦,櫻井淳, 田中淳二,森田毅,富田寿彦,堀和敏,渡 二郎,松本譽之,三輪洋人.
Organizer
JDDW2010一 般ポスター消P-159
Place of Presentation
横浜,神奈川
Year and Date
2010-10-13
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[Presentation] Down-regulation of claudin-4 and up-regulation of claudin-18 are associated with proliferative potential of intramucosal gastric cancer.2010
Author(s)
Chen X, Oshima T, Sakurai J, Tanaka J, Morita T, Tomita T, Kim Y, Hori K, Watari J, Matsumoto T, Miwa H.
Organizer
S1961 (Digestive Disease Week
Place of Presentation
New Orleans, Louisiana, USA)
Year and Date
2010-05-02
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[Book] H.pylori除菌による早期胃癌内視鏡治療後の異時性発癌の抑制効果(解説/特集)消化器 内科(1884-2895)54 巻 3号Page302-308(2012.03) H.pyloriと胃癌の基礎と臨床
Author(s)
渡 二郎,盛一健太郎,田邊裕貴,藤谷幹浩,富田寿彦,大島忠之,福井広一,堀 和敏,松本譽之,三輪洋人,高後 裕.
Publisher
科学評論社
