The functional analysis of IL-7 receptor in colitogenic memory Tcell.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590695
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OKADA Eriko 東京医科歯科大学, 医学部附属病院, 助教 (20376784)
• Co-Investigator(Kenkyū-buntansha): NEMOTO Yasuhiro 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (20456213) ; WATANABE Mamoru 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10175127)
• Project Period (FY): 2010 – 2012
• Keywords: IL-7 / IL-7R / メモリーT細胞 / 炎症性腸疾患

Research Abstract

As the final goal for the development of epoch-making radical treatment to inflammatory bowel disease (IBD), we have focused "colitogenic memory T cell" that continues being underlying in the body throughout the life. We have then proved the importance of the IL-7/IL-7 receptor (IL-7R) signal in the mechanism for the maintenance of colitogenic memory T cell and the importance of IL-7R signaling in colitis model. IL-7Rα was expressed in CD4+T cell in both normal mouse and colitis mouse. And the expression of IL-7Rα was up-regulated in the CD4+T cell with the onset of the colitis. These results suggested that IL-7/IL-7R signal in the CD4+T cell might be novel target for the therapy of the inflammatory bowel diseases.

Research Products

• [Journal Article] Modified single-operator method for double-balloonendoscopy (2012)
  • Author(s): Araki A, Suzuki S, Tsuchiya K, Oshima S, Okada E, Watanabe M
  • Journal Title: Dig Endosc Volume: 24(6) Pages: 470-4
  • DOI: doi:10.1111/j.1443-1661.2012.01321.x.
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report (2012)
  • Author(s): Araki A, Tsuchiya K, Oshima S, Okada E, Suzuki S, Akiyama JM, Fujii T, Okamoto R, Watanabe M
  • Journal Title: J Med Case Rep Volume: 6(1) Pages: 328
  • DOI: doi:10.1186/1752-1947-6-328.
  • Peer Reviewed
• [Journal Article] Histological Diagnosis of Follicular Lymphoma by Biopsy of Small Intestinal Normal Mucosa (2012)
  • Author(s): Okada E, Araki A, Suzuki S, Watanabe H, Ikeda T, Watanabe T, Kurata M, Eishi Y, Watanabe M
  • Journal Title: Dig Endosc Pages: 22
  • DOI: doi:10.1111/j.1443-1661.2012.01386.x.
  • Peer Reviewed
• [Journal Article] Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease (2011)
  • Author(s): Hyun SB, Kitazume Y, Nagahori M, Toriihara A, Fujii T, Tsuchiya K, Suzuki S,Okada E, Araki A, Naganuma M, Watanabe M
  • Journal Title: Inflamm Bowel Dis Volume: 17(5) Pages: 1063-72
  • DOI: doi:10.1002/ibd.21510.
  • Peer Reviewed
• [Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4 (2011)
  • Author(s): Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M
  • Journal Title: J Gastroenterol Volume: 46(2) Pages: 191-202
  • DOI: doi:10.1007/s00535-010-0346-x.
  • Peer Reviewed
• [Presentation] ダブルバルーン内視鏡を用いた潰瘍性大腸炎患者の小腸所見の検討 (2011)
  • Author(s): 岡田英理子
  • Organizer: 第81回日本消化器内視鏡学会総会
  • Year and Date: 2011-08-18