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2012 Fiscal Year Final Research Report

The effect of carbon monoxide in the intestinal inflammation

Research Project

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Project/Area Number 22590706
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

TAKAGI Tomohisa  京都府立医科大学, 医学(系)研究科(研究院), 講師 (70405257)

Co-Investigator(Kenkyū-buntansha) NAITO Yuji  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00305575)
半田 修  京都府立医科大学, 医学(系)研究科(研究院), 講師 (90381970)
Project Period (FY) 2010 – 2012
Keywords一酸化炭素 / 潰瘍性大腸炎 / クローン病 / 炎症性腸疾患 / 抗炎症作用 / 粘膜治癒
Research Abstract

An abundance of recent data on the cytoprotective and anti-inflammatory effect of carbon monoxide (CO) supports that CO is a promising therapeutic gas for various diseases. In the present study, we investigated whether the enema with CO-saturated saline as a novel therapeutic strategy was effective against intestinal inflammation. CO-saturated solution was made by bubbled 50% CO gas into saline. In results, the intrarectal administration of CO-saturated solution ameliorated TNBS-induced colitis and accelerated the healing of the colonic ulceration. Moreover, CO-saturated medium enhanced the migration of intestinal epithelial cells. Thus, the rectal administration of CO-saturated solution protected from the intestinal inflammation and accelerated the colonic ulcer healing. B ased on these data, CO mayrepresent a novel therapeutic approach for the treatment of inflammatory bowel disease.

  • Research Products

    (22 results)

All 2013 2012 2011 2010

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (5 results) Book (3 results)

  • [Journal Article] BTB and CNC homolog 1 (Bach1) deficiency ameliorates TNBS colitis in mice: Role of M2 macrophages and heme oxygenase-12013

    • Author(s)
      Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Higashimura Y, Katada K, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Muto A, Igarashi K, Yoshikawa T
    • Journal Title

      Inflamm Bowel Dis

      Volume: 19(4) Pages: 740-53

    • DOI

      doi:10.1097/MIB.0b013e3182802968

    • Peer Reviewed
  • [Journal Article] A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise2013

    • Author(s)
      Aoi W, Naito Y, Takagi T, Tanimura Y, Takanami Y, Kawai Y, Sakuma K, Hang LP, Mizushima K, Hirai Y, Koyama R, Wada S, Higashi A, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      Gut

      Volume: 62(6) Pages: 882-9

    • DOI

      doi:10.1136/gutjnl-2011-300776

    • Peer Reviewed
  • [Journal Article] Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression2012

    • Author(s)
      Higashimura Y, Naito Y, Takagi T, Mizushima K, Hirai Y, Harusato A, Ohnogi H, Yamaji R, Inui H, Nakano Y, Yoshikawa T
    • Journal Title

      J Gastroenterol

    • URL

      http://link.springer.com/ content/ pdf/10.1007%2Fs00535-012-0719-4.pdf

    • Peer Reviewed
  • [Journal Article] Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats2012

    • Author(s)
      Takagi T, Naito Y, Uchiyama K, Okuda T, Suzuki T, Tsuboi H, Mizushima K, Handa O, Yagi N, Ichikawa H, Yoshikawa T
    • Journal Title

      Med Gas Res

      Volume: 2(1) Pages: 23

    • DOI

      doi:10.1186/2045-9912-2-23

    • Peer Reviewed
  • [Journal Article] Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin.2012

    • Author(s)
      Takagi T, Naito Y, Okada H, Takaoka M, Oya-Ito T, Yamada S, Hirai Y, Mizushima K, Yoshida N, Kamada K, Katada K, Uchiyama K, Ishikawa T, Handa O, Yagi N, Konishi H, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 27 Suppl 3 Pages: 70-5

    • DOI

      doi:10.1111/j.1440-1746.2012.07076.x

    • Peer Reviewed
  • [Journal Article] Therapeutic potential of carbon monoxide (CO) for intestinal inflammation2012

    • Author(s)
      Naito Y, Uchiyama K, Takagi T, Yoshikawa T
    • Journal Title

      Curr Med Chem

      Volume: 19(1) Pages: 70-6

    • URL

      http://www.eurekaselect.com/75561/article

    • Peer Reviewed
  • [Journal Article] Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution2011

    • Author(s)
      Takagi T, Naito Y, Uchiyama K, Okuda T, Mizushima K, Suzuki T, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      World J Gastroenterol

      Volume: 17(33) Pages: 3802-9

    • DOI

      doi:10.3748/wjg.v17.i33.3802

    • Peer Reviewed
  • [Journal Article] Carbon monoxide liberated from carbon monoxide-releasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice2011

    • Author(s)
      Takagi T, Naito Y, Uchiyama K, Suzuki T, Hirata I, Mizushima K, Tsuboi H, Hayashi N, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      Dig Dis Sci

      Volume: 56(6) Pages: 1663-71

    • DOI

      doi:10.1007/s10620-010-1484-y.Epub2010Nov18

    • Peer Reviewed
  • [Journal Article] Suppression of indomethacin- induced apoptosis in the small intestine due to Bach1 deficiency2011

    • Author(s)
      Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Yamada S, Tuji T, Yoriki H, Horie R, Inoue K, Fukumoto K, Handa O, Ishikawa T, Kokura S, Minamiyama Y, Ichikawa H, Muto A, Igarashi K, Yoshikawa T
    • Journal Title

      Free Radic Res

      Volume: 45(6) Pages: 717-27

    • DOI

      doi:10.3109/10715762.2011.574287

    • Peer Reviewed
  • [Journal Article] Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases2011

    • Author(s)
      Naito Y, Takagi T, Uchiyama K, Yoshikawa T
    • Journal Title

      J Clin Biochem Nutr

      Volume: 48(2) Pages: 126-33

    • DOI

      doi:10.3164/jcbn.10-61

    • Peer Reviewed
  • [Journal Article] Endogenous hydrogen sulfide is an anti-inflammatory molecule in dextran sodium sulfate-induced colitis in mice2011

    • Author(s)
      Hirata I, Naito Y, Takagi T, Mizushima K, Suzuki T, Omatsu T, Handa O, Ichikawa H, Ueda H, Yoshikawa T
    • Journal Title

      Dig Dis Sci

      Volume: 56(5) Pages: 1379-86

    • DOI

      doi:10.1007/s10620-010-1461-5

    • Peer Reviewed
  • [Journal Article] Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-alpha expression2010

    • Author(s)
      Takagi T, Naito Y, Mizushima K, Akagiri S, Suzuki T, Hirata I, Omatsu T, Handa O, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      Dig Dis Sci

      Volume: 55 Pages: 2797-2804

    • DOI

      doi:10.1007/s10620-009-1112-x

    • Peer Reviewed
  • [Journal Article] The role of heme oxygenase and carbon monoxide in inflammatory bowel disease2010

    • Author(s)
      Takagi T, Naito Y, Uchiyama K, Yoshikawa T
    • Journal Title

      Redox Rep

      Volume: 15(5) Pages: 193-201

    • DOI

      doi:10.1179/174329210X12650506623889

    • Peer Reviewed
  • [Journal Article] Uchiyama K, Naito Y, Takagi T, Mizushima K, Hayashi N, Harusato A, Hirata I, Omatsu T, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T2010

    • Author(s)
      Uchiyama K, Naito Y, Takagi T, Mizushima K, Hayashi N, Harusato A, Hirata I, Omatsu T, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 391(1) Pages: 1122-6

    • DOI

      doi:10.1016/j.bbrc.2009.12.035.

    • Peer Reviewed
  • [Presentation] シンポジウム 1「炎症性腸疾患の免疫病態 -Bench&Bedside Heme oxygenase-1発現制御性転写因子Bach1の抑制は腸管炎症を改善する.2011

    • Author(s)
      高木智久、 内藤裕二、春里暁人、辻 俊史、寄木浩行、堀江隆介、内山和彦、堅田和弘、水島かつら、平井泰子、半田 修、八木信明、市川 寛、武藤哲彦、五十嵐和彦、吉川敏一
    • Organizer
      第48回日本消化器免疫学会総会
    • Place of Presentation
      金沢
    • Year and Date
      20110721-22
  • [Presentation] シンポジウム 5「炎症制御とガスバイオロジーの接点」一酸化炭素(Carbon monoxide: CO)による腸管炎症制御2011

    • Author(s)
      高木智久、 内藤裕二、内山和彦、吉川敏一
    • Organizer
      32回日本炎症・再生医学会
    • Place of Presentation
      京都
    • Year and Date
      2011-06-03
  • [Presentation] ベーシックサイエンス企画 シンポジウム 1「抗酸化環境応答と加齢」消化管炎症における抗酸化環境応答2011

    • Author(s)
      高木智久、内藤裕二、吉川敏一
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-27
  • [Presentation] Carbon monoxide (CO)-saturated sodium enema ameliorates trinitrobenzene sulfonic acid-induced colitis in rats2010

    • Author(s)
      Takagi T, Naito Y, Uchiyama K, Okuda T, Hirata I, Omatsu T, Mizushima K, Hayashi N, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshiakwa T
    • Organizer
      The 6thInternational Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-06-14
  • [Presentation] The role of BACH1 in Dextran Sodium Sulfate (DSS)-Induced Colitis in Mice2010

    • Author(s)
      Takagi T, Naito Y, Harusato A, Yamada S, Fukumoto K, Inoue K, Horie R, Mizushima K, Omatsu T, Hirata I, Yoshida N, Uchiyama K, Uchiyama K, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Yagi N, Kokura S, Ichikawa H, Muto A, Igarashi K, Yoshikawa T
    • Organizer
      The 111th Annual Meeting of the AGA Institute. Digestive Disease Week
    • Place of Presentation
      New Orleans, USA.
    • Year and Date
      2010-05-02
  • [Book] Free radicals in inflammatory bowel disease2011

    • Author(s)
      Takagi T, Naito Y, Yoshikawa T
    • Total Pages
      128-136
  • [Book] CO and its application to Gastrointestinal disease2011

    • Author(s)
      Naito Y, Uchiyama K, Takagi T, Yoshikawa T
    • Total Pages
      35-42
  • [Book] Role of hydrogen sulfide in colitis2011

    • Author(s)
      Takagi T, Naito Y, Hirata I, Yoshikawa T
    • Total Pages
      73-80

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Published: 2014-08-29  

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