2012 Fiscal Year Final Research Report
Analysis of cell-cell interaction among hepatic non-parenchymal
| Project/Area Number |
22590719
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TANAKA Minoru 東京大学, 分子細胞生物学研究所, 准教授 (80321909)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞間相互作用 |
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| Research Abstract |
Hepatic sinusoid is composed of stellate cells (HSCs) and sinusoidalendothelial cells. In this study, we focused on cell-cell interaction between HSCs and theother non-parenchymal cells (NPCs) at liver fibrosis. We found that Oncostatin M (OSM)directly induced TIMP-1 expression in HSCs and contributed to liver fibrosis bysuppressing the digestion of collagen fiber. Furthermore, OSM seemed to induce theactivation of HSCs indirectly via NPCs. Finally, overexpression of OSM in liver resulted infibrosis without apparent hepatic injury.
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[Book] Liver stem cells.2011
Author(s)
Itoh T, Tanaka M,Miyajima A
Total Pages
327-349
Publisher
Regenerati ve Medi ci ne f rom Protocol to Pati ent
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