2012 Fiscal Year Final Research Report
Role of hepatic innate lymphocytes at the liver injury
| Project/Area Number |
22590721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
ABO Toru 新潟大学, 医歯学系, 教授 (30005079)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Toshihiko 新潟大学, 医歯学系, 准教授 (70301182)
KAWAMURA Hiroki 新潟大学, 医歯学系, 講師 (20333495)
KANDA Yasuhiro 新潟大学, 医歯学系, 助教 (00436768)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肝臓 / 自己免疫性肝炎 / 自然リンパ球 / 肝障害 / NKT細胞 |
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| Research Abstract |
We analyzed the activation of the natural lymphocytes and the function of the hepatic lymphocyte on hepatitis. We found that hepatic NK cells activated strongly than other NK cells. This finding indicated hepatic natural lymphocytes had unique immunoresponses. In α-galactocylceramide-mediated hepatic injury, NKT cell promoted B-1 cell activation and autoantibody production. NKT cells also suppressed zymosan A-mediated granuloma formation in the liver.
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