2012 Fiscal Year Final Research Report
Analysis of genetic predisposition in relation to prognosis and response to therapy in liver diseases
| Project/Area Number |
22590733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Fusao 岡山大学, 大学院・医歯薬総合研究科, 助教 (10534571)
SHIMIZU Kenji 岡山大学, 大学院・医歯薬総合研究科, 特命教授 (10037286)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ウイルス肝炎 / 脂肪肝 / 肝細胞癌 / 遺伝子多型 |
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| Research Abstract |
We demonstrated an association between IL28B and ITPA genotypes and response to antiviral therapy and adherence to therapy, respectively, in chronic hepatitis C patients. Association between PNPLA3 genotype and non-alcoholic fatty liver diseases or severe steatois in chronic hepatitis C and association between PNPLA3 genotype and development of hepatocellular carcinoma (HCC) in chronic hepatitis C patients who had been treated with antiviral therapy were revealed. Finally, association between PNPLA3 genotype and HCC of non-viral origin and association between MICA genotype and hepatitis C virus-related HCC were demonstrated by an analysis of a substantial number of patients.
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[Journal Article] The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis2013
Author(s)
Yasuto Takeuchi, Fusao Ikeda, Yuki Moritou, Hiroaki Hagihara, Tetsuya Yasunaka, Kenji Kuwaki, Yasuhiro Miyake, Hideki Ohnishi, Shinichiro Nakamura, Hidenori Shiraha, Akinobu Takaki, Yoshiaki Iwasaki, Kazuhiro Nouso, Kazuhide Yamamoto
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Journal Title
Journal of Gastroenterology
Volume: 48巻
Pages: 405-412
DOI
Peer Reviewed
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