2012 Fiscal Year Final Research Report
Impact of viral amino acid substitutions and host IL28B polymorphism on replication and susceptibility to interferon of hepatitis C virus
| Project/Area Number |
22590737
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | C型慢性肝炎 / インターフェロン / IL38B遺伝子多型 / HCV Core変異 / ISDR / ヒト肝細胞キメラマウス |
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| Research Abstract |
Using human hepatocyte chimeric ice, we found that hepatitis C virus (HCV) replication levels and response to interferon (IFN) are affected by mutations in the ISDR, not by amino acid substitutions in HCV Core region. We also found that the effect of IFN was significantly greater, and intrahepatic expression levels of IFN-stimulated genes were significantly higher in mice with the favorable IL28B allele.
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[Journal Article] Impact of viral amino acid substitutions and host IL28B polymorphism on replication and susceptibility to interferon of hepatitis C virus2011
Author(s)
Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, Tateno C, Yoshizato K, Nakamura Y, Kamatani N, Chayama K
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Journal Title
Hepatology
Volume: 54(3)
Pages: 764-771
Peer Reviewed
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[Journal Article] Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state2011
Author(s)
Abe H, Hayes CN, Ochi H, Tsuge M, Miki D, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Kamatani N, Chayama K
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Journal Title
J Med Virol
Volume: 83(9)
Pages: 1597-607
Peer Reviewed
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