2012 Fiscal Year Final Research Report
Pathogenesis of autoimmune hepatic injury through the migration of immunocompetent cells into the liver
| Project/Area Number |
22590744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAI Takanori 慶應義塾大学, 医学部, 准教授 (40245478)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肝臓学 |
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| Research Abstract |
Liver-infiltrating CCR9^+macrophages play a key role in promoting proliferation of CD4^+ T cells and generation of IFN-γ-producing Th1 cells as well as NKT cell activation in Concanavalin A-induced acute hepatitis. In terms of the clinical relevance, not
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[Journal Article] CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis.2012
Author(s)
Nakamoto N, Ebinuma H, Kanai T, Chu PS, Ono Y, Mikami Y, Ojiro K, Lipp M, Love PE, Saito H, Hibi T.
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Journal Title
Gastroenterology
Volume: 142
Pages: 366-376
Peer Reviewed
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[Journal Article] CCR9(+) plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice.2012
Author(s)
Mizuno S, Kanai T, Mikami Y, Sujino T, Ono Y, Hayashi A, Handa T,Matsumoto A, Nakamoto N, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T.
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Journal Title
Immunol Lett
Volume: 146
Pages: 64-69
Peer Reviewed
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