2012 Fiscal Year Final Research Report
Comprehensive study to elucidate molecular mechanisms behind intrahepatic cholestasis
| Project/Area Number |
22590746
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Keywords | 胆汁酸トランスポーター / 胆汁うっ滞 / 胆汁分泌 / ウルソデオキシコール酸 |
|---|
| Research Abstract |
Intrahepatic cholestasis is a difficult-to-treat disease. Although ursodeoxycholic acid has choleretic effect and is widely used to treat cholestasis, molecular mechanisms behind this effect remain unknown. In this study we demonstrated that ursodeoxycholic acid induces choleresis by stabilizing bile salt export pump in the apical membrane.
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Research Products
(22 results)
